ד"ר יחיאל אלקבץ

דיקאנט ומנהל הפקולטה לרפואה עובד מחקר
ניווט מהיר:
ד"ר יחיאל אלקבץ
טלפון פנימי: 03-6406781
טלפון נוסף: 03-6406268
פקס: 03-6407432

Academic Appointments

Positions 

Present Lecturer, Department of Cell & Developmental Biology, Tel Aviv University
2009-Present  Head, Laboratory for Pluripotent and Neural Stem Cell Biology, Department of Cell and Developmental Biology, Tel Aviv University
2007-2008 Program Advisor and Coach, The Project A.L.S., The Jenifer Estess Laboratory for Stem Cells and ALS Research, Columbia University, NY
2004-2009 Post-doctoral Fellow with Dr. Lorenz Studer, Laboratory of Stem Cell and Tumor Biology, Developmental Biology Program, Sloan-Kettering Institute for Cancer Research, NY

 

Education

Education 

1998-2004 Ph.D. in Molecular and Cellular Biology, Dept. of Biochemistry Tel Aviv University, Israel
1995-1997 M.Sc. in Molecular and Cellular Biology, Dept. of Biochemistry Tel Aviv University, Israel
1992-1994 B.Sc. in Biological Sciences Tel Aviv University, Israel
1989-1991 Diploma in Practical Engineering, Electronics and Computers ORT Haifa College, Haifa, Israel

 

Research

Our lab makes use of human embryonic stem cells in order to elucidate developmental programs in the human nervous system, with particular interest in neural stem cells (NSCs).
 
The NSC ontogeny dogma predicts that early developing NSCs are highly potent and can yield all nervous system cell types, but they rapidly lose this potential as development proceeds. Because NSCs behave similarly in culture, they are almost useless for studying differentiation to most neuronal cell types – a major impediment for understanding basic development and application to regenerative medicine.
 
Our main goal is to learn the biology of early neural stem cells in the lab in order to develop strategies for standardizing their growth in culture without loss of differentiation potential. Such continuously self renewing cells will serve as a gold standard NSCs for studying nervous system development and disease, making cells for therapy and discovering novel drugs.
 
We use a variety of techniques in mouse and human embryonic stem cells and NSCs cells including transgenics (genetic labeling), viral expression of coding genes and microRNAs, classic stem cell assays, FACS-sorting and stem cell differentiation, and two-photon/confocal live cell imaging.

 

Publications

Edri, R.*, Yaffe, Y.*, Ziller, M.J., Mutukula, N., Volkman, R., David, E., Jacob-Hirsch, J., Malcov, H., Levy, C., Rechavi, G., Gat-Viks, I., Meissner, A., and Elkabetz Y. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors (2015). Mar 23;6:6500. doi: 10.1038/ncomms7500.

 

Ziller, M.J.*, Edri, R.*, Yaffe, Y., Donaghey, J., Pop, R., Mallard, W., Issner, R., Gifford, C.A., Goren, A., Xing, J., Gu, H., Cacchiarelli, D., Tsankov, A.M., Epstein, C., Rinn, J.L., Mikkelsen, T.S., Kohlbacher, O., Gnirke, A., Bernstein, B.E., Elkabetz, Y.**, and Meissner, A.** Dissecting neural differentiation regulatory networks through epigenetic footprinting. Nature. 2015 Feb 19;518(7539):355-9.

 

Lafaille, F.G., Pessach, I.M., Zhang, S.Y., Ciancanelli, M.J., Herman, M., Abhyankar, A., Ying, S.W., Keros, S., Goldstein, P.A., Mostoslavsky, G., Ordovas-Montanes, J., Jouanguy, E., Plancoulaine, S., Tu, E., Elkabetz, Y., Al-Muhsen, S., Tardieu, M., Schlaeger, T.M., Daley, G.Q., Abel, L., Casanova, J.L., Studer, L., and Notarangelo, L.D. Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature 491, 769-773. (2012)

 

Lipchina, I., Elkabetz, Y., Hafner, M., Sheridan, R., Mihailovic, A., Tuschl, T., Sander, C., Studer, L., and Betel, D. Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Genes Dev 25, 2173-2186. (2011)

 

Fasano, C.A., Phoenix, T.N., Kokovay, E., Lowry, N., Elkabetz, Y., Dimos, J.T., Lemischka, I.R., Studer, L., and Temple, S. Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev 23, 561-574. (2009)

 

Elkabetz, Y., Studer, L. Human Embryonic Stem Sell-Derived Neural Rosettes and Neural Stem Cell Progression. Control and Regulation of Stem Cells. Cold Spring Harbor Symposia on Quantitative Biology. Grodzicker, T., Stewart, D., Stillman, B., (Editors). Cold Spring Harb Symp Quant Biol. 2009; 73:377-87.

 

Elkabetz, Y., Panagiotakos, G., Al Shamy, G., Socci, N.D., Tabar, V., Studer, L. Human ES Cells-Derived Neural Rosettes Reveal a Functionally Distinct Early Neural Stem Cell Stage. ART COVER ARTICLE; Genes & Development 2008; 22:152-165.

 

Lee G., Elkabetz Y.*, Kim H.* (Equal), Al Shamy, G., Panagiotakos, G., Barberi, T., Tabar, V., Studer, L. Isolation and Directed Differentiation of Neural Crest Stem Cells Derived from Human Embryonic Stem Cells. Nature Biotechnology 2007; 25:1468-75.

 

Lee, H., Al Shamy, G., Elkabetz, Y., Schofield, C.M., Harrsion, N.L., Panagiotakos, G., Socci, N.D., Tabar, V., Studer, L. Directed Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Motoneurons. Stem Cells 2007; 25:1931-9.

 

Elkabetz, Y., Ofir, A., Argon, Y., Bar-Nun, S. Alternative Pathways of Disulfide Bond Formation Yield Secretion-Competent, Stable and Functional Immunoglobulins. Molecular Immunology 2008; 46:97-105.

 

Elkabetz, Y., Argon, Y., Bar-Nun, S. Cysteines Underlie BiP-Mediated Retention of Unassembled Immunoglobulin Heavy-Chains. Journal of Biological Chemistry 2005; 15:14402-12.

 

Elkabetz, Y., Shapira I., Rabinovich, E., Bar-Nun S. Distinct Steps in Dislocation of Luminal Endoplasmic Reticulum-Associated Degradation Substrates: Roles of Endoplasmic Reticulum-Bound p97/Cdc48p and Proteasome. Journal of Biological Chemistry 2004; 279:3980-9.

 

Elkabetz, Y., Kerem, A., Tencer, L., Winitz, D., Kopito, R.R., Bar-Nun S. Immunoglobulin Light Chains Dictate Vesicular Transport-Dependent and -Independent Routes for IgM Degradation by the Ubiquitin-Proteasome Pathway. Journal of Biological Chemistry 2003; 278:18922-9.  

 

אוניברסיטת תל-אביב, ת.ד. 39040, תל-אביב 6997801
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