Education
1985-1988 B.Sc. Life Science, Hebrew University, Israel
1991-1993 M.Sc. Faculty of Medicine, Technion, Israel, Developmental Immunology
1993-1997 Ph.D Faculty of Medicine, Technion, Israel, Human Immunology
Academic and other positions
-1999-2001 Postdoctoral fellowship, Cooperation between Hadassah Medical Center Jerusalem and Tel-Aviv University. Autoimmunity and pregnancy
-Lecturer, Sackler Faculty of Medicine.
-Researcher, Oncogenetic Laboratory, Meir medical center
Research areas
We focus on the effect of pregnancy microenvironment on the pathogenesis of cancer. In particular, we study the interaction between human placenta to breast and ovarian cancer cells. Furthermore, we explore pathways involved in placental implantation that resembles cancer implantation and may shed light on metastases growth.
Cancer is coincides about one in 1,000 pregnancies. Very little information exists regarding the effect of pregnancy on cancer cells and the effect of cancer therapy on pregnancy. One of the most common malignant tumors associated with pregnancy is breast carcinoma. Pregnant women with breast cancer present with a more advanced disease compared with non-pregnant women. Nevertheless, metastases to the product of conception are a rare event. In the last few years we focused on understanding the pathways and mechanisms involved in eliminating cancer growth in the placental area on the one hand and in facilitating cancer progression during pregnancy on the other. Our research entails the use of cell lines, explants of human placenta and a variety of cellular and molecular techniques. Furthermore, we explore new pathways involved in placental implantation and the effect of chemotherapeutic drugs on these pathways. Understanding the causes for the advanced cancer during pregnancy and the placental mechanisms for eliminating metastases may afford novel and more efficient treatment for the patients.
List of Publications (2008-2012):
- Tartakover Matalon S, Drucker L, Fishman A, Ornoy A, Lishner M.
The role of Heat Shock Protein 27 in extravillous trophoblast differentiation.
J Cellular Biochemistry 103(3):719-729, 2008.
- Lishner M, Zismanov V, Tohami T, Tartakover Matalon S, Drucker L
Tetraspanins affect myeloma cell fate via Akt signaling and FoxO activation.
Cellular Signaling. 20(12):2309-16, 2008.
- Zismanov V, Lishner M, Tartakover Matalon S, Elis A, Drucker L.
Tetraspanin induced death of myeloma cell lines is autophagic and involves increased UPR signaling. Brit J Cancer 101(8):1402-9, 2009.
- Tartakover-Matalon S, Mizrahi A, Epstein G, Shneifi A, Drucker L, Pomeranz M, Fishman A, Radnay J, Lishner M. Breast cancer characteristics are modified by first trimester human placenta: in vitro co-culture study. Hum Reprod 25(10):2441-54, 2010.
- Epstein Shochet G*, Tartakover-Matalon S*, Drucker L, Pomeranz M, Fishman A, Rashid G, Oron-Karni V, pasmanik-Chor M, Lishner M. Hormone-dependent placental manipulation of breast cancer cell migration. Hum Reprod 27(1):73-88, 2012.
- Attar-Schneider O, Drucker L, Zismanov V, Tartakover Matalon S, Rashid G, Lishner M.
Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells. Lab Invest 92(2): 178–190, 2012.
- Zismanov V*, Drucker L*, Oshrat Attar-Schneider, Tartakover matalon S, Pasmanik-Chor M, Lishner M. Tetraspanins stimulate protein synthesis in myeloma cell lines. J Cell Biochem 113(7):2500-10, 2012.
- Kitroser E, Pomeranz M, Epstein Shochet G, Fishman A, Drucker L, Sadeh-Mestechkin D, Lishner M, Tartakover Matalon S. The involvement of eukaryotic translation initiation factor 4E in extravillous trophoblast cell function. Placenta 33(9):717-24, 2012.
Chapters in books:
Heat Shock Proteins. Edited by: Morel and Camille Vincent Published by: Nova publishers, 2008 Chapter in Heat Shock Proteins : Tartakover Matalon S, Drucker L, Lishner M, The Involvement of Heat Shock Protein 27 in Normal and Cancer Cell Migration; pp. 185-195
Cancer in Pregnancy and Lactation. Edited by: Gideon Koren and Michael Lishner Published by: Cambridge University Press, 2011 Chapter in Cancer in Pregnancy and Lactation: Chapter 24- Tartakover-Matalon S, Drucker L and Lishner M, Effects of the placenta on metastatic breast cancer; pp. 195-205
Grants (2008-2012)
2012- Djerassi-Elias Institute of Oncology
