פרופ' נתן בורנשטיין

 

A. Education

                       

                                                                                                Degree or    

                                                                                                Professional

Period of study     Name of University            subject          License          awarded

 

1970-73                   University of Sienna              Medicine                                                       

                                  Sienna, Italy

 

1973-79                   Technion Medical                  Medicine        MD                  1979

                                  School, Hifa

 

Date of receiving specialixation certificate: 11 September, 1984

Title of Doctoral dissertation: Dextran 40 in acute ischemic stroke

Name of Supervisor: Dr. Jacob Vardi

 

 

B. Further Education

 

                                                                                                Degree or    

                                                                                                Professional

Period of study     Name of University            subject          License          awarded

 

1978-83Tel-Aviv University,                neurology       Israeli Board      1983

Sackler Faculty of                 (residence)    certified in     

Medicine                                                        Neurology

 

1979-83Tel-Aviv University                 Post graduate

Sackler Faculty of                studies in Neurology

Medicine

 

1984-87Sunnybrook Medical             M.R.C stroke

Center, University of Fellowship

Toronto                                                                                                          

 

Reseach areas

 

Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol

Recent studies have demonstrated that even survivors of mild stroke experience residual damage, which persists and in fact increases in subsequent years. About 45% of stroke victims remain with different levels of disability. Identifying factors associated with poststroke cognitive and neurological decline could potentially yield more effective therapeutic opportunities. AIMS AND HYPOTHESIS: We hypothesize that data based on biochemical, neuroimaging, genetic and psychological measures can, in aggregate, serve as better predictors for subsequent disability, cognitive and neurological deterioration, and suggest possible interventions.The Tel-Aviv Brain Acute Stroke Cohort (TABASCO) study is an ongoing, prospective cohort study that will recruit approximately 1125 consecutive first-ever mild-moderate stroke patients. It is designed to evaluate the association between predefined demographic, psychological, inflammatory, biochemical, neuroimaging and genetic markers, measured during the acute phase, and long-term outcome: subsequent cognitive deterioration, vascular events (including recurrent strokes), falls, affect changes, functional everyday difficulties and mortality.This study is an attempt to comprehensively investigate the long-term outcome of mild-moderate strokes. Its prospective design will provide quantitative data on stroke recurrence, the incidence of other vascular events and the evaluation of cognitive, affective and functional decline. Identifying the factors associated with poststroke cognitive and functional decline could potentially yield more effective therapeutic approaches

List of Publications (2008-2013)

 

84. A Catz, V Bluvshtein, I Pinhas, S. Akselrod, I Gelernter, T Nissel, Y Vered,
        Natan M. Bornstein, AD Korczyn

       Cold pressor test tetraplegia and paraplegia suggests an independent role  

       of the thoracic spinal cord in the hemodynamic responses to cold.

       Spinal Cord (2008) 46, 33-38 (clinical neurology IF=2.071 R=79/156)

 

85. Shani Shenhar-Tsarfati, Einor Ben Assayag, Irena Bova, Ludmila Shopin,

        Michael Cohen, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein

        Persistent hyperfibrinogenemia in acute ischemic stroke/

        transient ischemic attack (TIA)

        Thromb Haemost 2008;99:169-173 (Hematology, IF=3.803 Rank=15/62

        Peripheral Vascular Disease, IF=3.803 Rank=12/56)

 

86. Salim Yusuf, D.Phil, Hans-Christoph Diener, Ralph L. Sacco,

      Daniel Cotton, Stephanie Ôunpuu, William A. Lawton,  Yuko Palesch,

      Reneé H. Martin,Gregory W. Albers, Philip Bath, Natan M. Bornstein, at el.
      Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events
      N Engl J Med 2008; 359:1225-37 (Medicine, General & Internal IF=50.017

     Rank=1/107)

 

87. Ralph L. Sacco, Hans-Christoph Diener, Salim Yusuf, D.Phil.,

     Daniel Cotton Stephanie Ôunpuu, William A. Lawton, Yuko Palesch,

     Reneé H. Martin, Gregory W. Albers, Philip Bath, Natan M. Bornstein, at el.

     Aspirin and Extended-Release Dipyridamole versus Clopidogrel for         

     Recurrent Stroke.
     N Engl J Med 2008; 359:1238-51 (Medicine, General & Internal IF=50.017

     Rank=1/107)

 

88. Hans-Christoph Diener, Ralph L Sacco, Salim Yusuf DPhil, Daniel Cotton,

      Stephanie Ôunpuu, William A Lawton, Yuko Palesch, Reneé H Martin,

      Gregory W Albers, Philip Bath, Natan M. Bornstein, at el.
      Effects of aspirin plus extended-release dipyridamole versus clopidogrel
      and  telmisartan on disability and cognitive function after

      recurrent  stroke in patients with ischemic stroke in the

      Prevention   Regimen for Effectively

      Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and   
      placebo controlled study

     Lancet Neurol 2008;10:875-84 (Clinical Neurology IF=14.270 Rank=1/156)

 

89. Ben Assayag E , Bova I, Berliner S, Shapira I, Bornstein NM.

      Erythrocyte aggregation as an early biomarker in patients with asymptomatic 

      carotid stenosis.

      Dis Markers. 2008;24(1):33-9. (Biotechnology & applied microbiology IF=2.303

      R=61/144, Genetics &heredity 81/138, Medicine, research & experimental 

      IF=2.303 R=38/83, Pathology IF=2.303 R=28/69)

 

90. Shenhar-Tsarfaty S, Assayag EB, Bova I, Shopin L, Berliner S, 

      Shapira I, Bornstein NM.

      Early signaling of inflammation in acute ischemic stroke:

      clinical and rheological implications.

      Thromb Res. 2008;122(2):167-73. (Hematology, IF=2.449 Rank=31/62

      Peripheral Vascular Disease IF=2.449 Rank=28/56)

 

91. Kesler A, Irge D, Rogowski O, Bornstein N, Berliner S, Shapira I, Shani ST,

      Ben Assayag E.

      High- sensitivity C-reactive protein measurements in patients with

      non-arteritic anterior ischaemic optic neuropathy: a clue to the presence

      of a microinflammatory response.

      Acta Ophthalmol. 2009; 87(2):216-21. (Ophthalmology IF=2.138 R=15/48)

 

92. Hans-Christoph Diener , Dietmar Schneider , Yair Lampl , Natan M. Bornstein ,   

      Alexander Kozak , Gilad Rosenberg et al.

      DP-b99, a membrane-activated metal ion chelator, as neuroprotective 

      therapy in ischemic stroke.

      Stroke. 2008 Jun;39(6):1774-8. (Clinical Neurology,IF=6.499 Rank=6/156,

      Peripheral Vascular Disease IF=6.499 Rank=7/56)

 

93. Koton S, Tanne D, Bornstein NM.

       Burden of stroke in Israel.

       Int J Stroke. 2008 Aug;3(3):207-9 (Peripheral Vascular Disease IF=2.000

       R=31/56)

 

94. Oláh L, Raiter Y, Candale C, Molnár S, Rosengarten B, Bornstein NM,

      Csiba L. Visually evoked cerebral vasomotor response in smoking and

      Visually evoked cerebral vasomotor response in smoking and nonsmoking young

      adults, investigated by functional transcranial Doppler.

      Nicotine Tob Res. 2008 Feb;10(2):353-8. (Public Environmental & Occupational   

      Health IF=2.539 R=27/105)

 

95. Alexander Y Gur , Ludmila Shopin, Natan Bornstein

      Lessons Learned from 2 Years' Experience in Intravenous Thrombolysis for

      Acute Ischemic Stroke in Single Tertiary Medical Center

      IMAJ 2009;11:714-718 (IF=0.626)

 

96. Ben Assayag E, Shenhar-Tsarfaty S, Bova I, Berliner S, Usher S, Peretz H,

      Shapira I, Bornstein NM.

      Association of the -757T>C polymorphism in the CRP gene with

      circulating C-  reactive protein levels and carotid atherosclerosis

       Thromb Res. 2009 Sep;124(4):458-62. Epub 2009 May 9(Hematology, IF=2.449    

       Rank=31/62 Peripheral Vascular Disease IF=2.449 Rank=28/56)

 

97.  Boms N, Yonai Y, Molnar S, Rosengarten B, Bornstein NM, Csiba L,

       Olah L

       Effect of Smoking Cessation on Visually Evoked Cerebral Blood Flow

       Response in Healthy Volunteers

       J Vasc Res. 2009 Nov 6;47(3):214-220 (Physiology IF=2.792 R=29/74,

       Peripheral Vascular Disease IF=2.792 R=23/56)

 

98  .Khurana D, Kaul S, Bornstein NM; ImpACT-1 Study Group

       Implant for augmentation of cerebral blood flow trial 1: a pilot study

       evaluating the safety and effectiveness of the Ischaemic Stroke

       System for treatment of acute ischaemic stroke.

       Int J Stroke. 2009 Dec;4(6):480-5 (Peripheral Vascular Disease IF=2.000

       R=31/56)

 

99. Yvonne Schwammenthal, Natan Bornstein, Ehud Schwammenthal,   

       Roseline Schwartz, Uri Goldbourt, Rakefet Tsabari, Silvia Koton,

       Ehud Grossman, David  Tanne  

       Relation of Effective Anticoagulation in Patients With Atrial

       Fibrrilationto Stroke Severity and Survival (from the National

       Acute Stroke Israeli Survey [NASIS])

       Am J Cardiol 2010;105:411-416 (IF= 3.905)

 

100.Silvia Koton, David Tanne, Manfred S. Green, Natan M. Bornstein

       Mortality and Predictors of Death 1 Month and 3 Years after first-ever  

       Ischemic Stroke: Data from the First National Acute Stroke Israeli Survey

       (NASIS 2004)

       Neuroepidemiology 2010;34:90-96 (Clinical Neurology, IF=1.737 Rank=93/156

       Public Environmental & Occupational Health, IF=1.737 Rank=54/150)

 

101. I. Kimiagar, A.Bass, J.M. Rabey, N.M. Bornstein and A.Y.Gur

        Long-term follow-up of patients with asymptomatic occlusion of the 

        internal carotid artery with good and impaired cerbral vasomotor reactivity      

        Eur J of Neurol 2010;17:1285-1290 (Clinical Neurology, IF=2.732 R=52/156)

 

 

102. S. Koton, NM Bornstein, R. Tsabari, D. Tanne

        Derivation and validation of the Prolonged Length of Stay score in

        acute  patients

        Neurology 2010;74;1511-1516 (Clinical Neurology IF=7.043 R=4/156)

 

103. Hugh S. Markus, Alice Kink, Martin Shipley, Raffi Topakian, Marisa Cullinane,                           

        Sheila Reihill, Natan M. Bornstein, Arjen Schaafsma

        Asymptomatic embolisation for prediction of stroke in the Asymptomatic  

      Carotid Emboli Study Study (ACES): a prospective observational study.

      Lancet Neurol. 2010;9:663-71 (Clinical Neurology IF=14.270 

      Rank=1/156)

 

104. Gur AY, Gucuyener D, Korczyn AD, Uzuner N, Gilutz Y, Ozdemir G,

      Bnornstein NM

      Cerebral Vasomotor reactivity and dementia after ischemic Stroke

      Acta Neurol Scan:  2010 122:383-388 (IF=2.317)

 

105. Urshansky N, Mausner-Fainberg K, Auriel E, Regev K, Borntein NM, Karni A,

       Reduced production of noggin by immune cells of patients with relapsing-remitting multiple sclerosis.

J Neuroimmunol. 2011. (1-2):171-8 (IF 2.901)

 

111. Auriel E, Bornstein NM, Berenyi E, Varkonyi I, Gabor M, Majtenyi K, Szepesi R,
Goldberg I, Lampe R, Csiba L.

Clinical, radiological and pathological correlates of leukoaraiosis.

Acta Neurol Scand. 2011;123(1):41-7 (IF=2.317)

 

112. G. Ntaios , C. Abatzi  , M. Alexandrou  , D. Lambrou  , S. Chatzopoulos  , M. Egli , J. Ruiz  , N. Bornstein  , P. Michel.

         Persistent hyperglycemia at 24-48 hours in acutely hyperglycemic stroke patients is not associated with worse functional outcome .

Cerebrovascular Diseases (IF=2.987  R= 58/185)

 

113. Auriel E, Karni A, Bornstein NM, Nissel T, Gadoth A, Hallevi H.

Extra-cranial venous flow in patients with multiple sclerosis

J Neurol Sci. 2011;309:102-104  ( IF=2.167 R=85/185)

 

114. Rosenberg G, Bornstein N, Diener HC, Gorelick PB, Shuaib A, Lees K;

The Membrane-Activated Chelator Stroke Intervention (MACSI) Trial of DP-b99 in acute ischemic stroke: a randomized, double-blind, placebo-controlled, multinational pivotal Phase III study.

Int J Stroke. 2011; (6):362-367 (IF=2.000 R=31/56)

 

115. Shuaib A, Bornstein NM, Diener HC, Dillon W, Fisher M, Hammer MD, Molina CA, Rutledge JN, Saver JL, Schellinger PD, Shownkeen H;

Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial.

Stroke. 2011;42(6):1680-90 (IF=6.499 Rank=6/156)

 

116. Bornstein N, Korczyn A

Asymptomatic carotid artery stenosis (ACAS).

J Neural Transm. 2011;118(4):629. (IF= 2.597 Rank=73\185)

 

117. Gross B, Feldman-Idov Y, Molshatzki N, Azrilin O, Goldbourt U, Bornstein NM, Tanne D.

Ethnic variations in acute ischemic stroke: findings from the National Acute Stroke Israeli Survey (NASIS).

Cerebrovasc Dis. 2011;31(5):506-10 (IF=2.987  R= 58/185)

 

118. Avi Gadoth, Eitan Auriel, Hila Shaim Natan M. Bornstein,

        Periprocedural Complication Rate of Carotid Endarterectomy versus Carotid    

Angioplasty and Stenting: A Retrospective Study and Review of the Literature

IMAJ 2011: 13: October: 601-604

 

119. Vered Gadidi, MSc, Michal Katz-Leurer, PhD, Eli Carmeli, PhD,

        Natan M. Bornstein, MD 

Long-Term Outcome Poststroke: Predictors of Activity Limitation and Participation Restriction

Arch Phys Med Rehabil 2011;92:1802-8.

 

 

 

 

 

120. Einor Ben Assayag, Amos D. Korczyn, Nir Giladi, Uri Goldbourt

        Sholmo Berliner,Shani Shenhar-Tsarfaty, Efrat Kliper, Hen Hallevi,  

        Ludmila Shopin, Talma Hendler

        Dafna Ben Baashat1, Orna Aizenstein1, Hermona Soreq4, Noomi Katz5, Zahava     

        Solomon, Anat Mike, Sali Usher, Jeff M. Hausdorff, Eitan Auriel, Itzhak   

        Shapira, and Natan M. Bornstein

        Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort          

        (TABASCO) study protocol

        Int J Stroke. 2012:7(4):341-7

 

 

 121.Hallevi H, Walker KC, Kasam M, Bornstein N, Grotta JC, Savitz SI.

        Inflammatory response to intraventricular hemorrhage: time course, magnitude          

        and effect of t-PA

        J Neurol Sci. 2012 Apr 15;315(1-2):93-5

 

122.Wolf-Dieter Heiss, Micahel Brainin, Natan M Bornstein, Jaako Tuomilehto and

       Zhen Hong

       Cerebrolysin in Patients with Scute Ischemic Stroke in Asia: Results of a

       Double – Blind, Placebo-conrolled Randomized Trial

       Stroke. 2012;43:00-00

 

123. Gerhard-Michael von Reutern, MD, PhD; Michael-Wolfgang Goertler, MD, PhD; Natan        

        M. Bornstein, MD; Massimo Del Sette, MD; David H. Evans, PhD, DSc; Andreas

        Hetzel, MD, PhD; Manfred Kaps, MD, PhD; Fabienne Perren, MD, PhD; Alexander

       Razumovky, PhD; Toshiyuki Shiogai, MD, PhD;Ekaterina Titianova, MD, PhD, DSc;

       Pavel Traubner, MD, PhD; Narayanaswamy Venketasubramanian, MD;Lawrence K.S.

       Wong, MD; Masahiro Yasaka, MD, PhD; on behalf of the Neurosonology Research

       Group of the World Federation of Neurology

       Grading Carotid Stenosis Using Ultrasonic Methods

       Stroke. 2012;43:916-921;

 

124. Eitan Auriel, Laszlo Csiba, Ervin Berenyi, Ildiko Varkonyi, Gabor Mehes,

       Lazlo Kardos, Arnon Karni and Natan M. Bornstein

       Leukoaraiosis is associated with arterial wall thikness: A quantative analysis

       Neuropathology. 2012;32(3):227:33

 

125. David Tanne, MD; Silvia Koton, PhD; Noa Molshazki, MSc; Uri Goldbourt, PhD; Tamar  

        Shohat, PhD; Rakefet Tsabari, MD; Ehud Grossman, PhD; Natan M. Bornstein, MD

        Trends in Management and Outcome of Hospitalized Patients With Acute Stroke and

        Transient Ischemic Attack The National Acute Stroke Israeli (NASIS) Registry  

        Stroke. 2012;43:2136-2141

 

126. Einor Ben-Assayag,  MilijaMijajlovic, Shani Shenhar-Tsarfaty,  Irena Bova,

        Ludmila Shopin,  and Natan M. Bornstein

        Leukoaraiosis Is a Chronic Atherosclerotic Disease

        The Scientific World Journal Volume 2012 (2012), Article ID 532141, 6 pages

 

 

127. Silvia Koton David Tanne, Natan M. Bornstein on behalf of the NASIS     

       Investigators

       Ischemic Stroke on Awakening: Patients’ Characteristics, Outcomes and Potential for    

         Reperfusion Therapy 

         Neuroepidemiology 2012;39:149–153

 

128. Silvia Koton, Noa Molshatzki, Natan M. Bornstein, David Tanne

on behalf of the NASIS Investigators

Low Cholesterol, Statins and Outcomes in Patients with First-Ever Acute Ischemic Stroke

Cerebrovasc Dis 2012;34:213–220

 

129. Kennedy R. Lees, Natan Bornstein, Hans-Chrisoph Diener, Philip B Gorelick, Gilad

        Rosenberg, Ashfaq Shuaib; for the MACSI investigators.

        Results of Membrane-Activated Chelator Stroke Intervention Randomized Trial of 

        DP-b99 in Acute Ischemic Stroke.

        Stroke. 2013; 44: XXX-XXX).