ד"ר אנג'לה רובן

סגל אקדמי בכיר בחוג לסיעוד-תכנית כללית
חוג לסיעוד-תכנית כללית סגל אקדמי בכיר
ד"ר אנג'לה רובן
טלפון פנימי: 03-6406259
פקס: 03-6409496
משרד: מקצוע הבריאות

השכלה

CV

מינויים אקדמיים

Research topic: Glutamate excitotoxicity and blood-glutamate scavenging in acute and chronic diseases

Research methods:  HPLC, intracranial mouse and rat tumor models, brain metastatic animal models, neurotrauma animal models, behaviora tests, immunohistochemistry, pharmacodynamics and pharmacokinetics analysis, biochemical analysis of liver enzymes activity in a blood sample.

 

Main projects in the lab include:

  1. Blood glutamate scavenging as a novel neuroprotective treatment in the neurotrauma.
  2. Role of blood liver enzyme and glutamate levels and the pathophysiology of neurodegenerative and malignant diseases.
  3. Blood glutamate scavenging in the prevention of brain tumor invasiveness.

  

Publications

Avissar, S, Matuzany-Ruban, A, Tzukert, K, Schreiber, G.: b-arrestin-1 levels are reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. Am. J. Psychiatry Vol. 161; pp.2066-72, 2004. 

 

Matuzany-Ruban, A, Avissar, S, Schreiber, G.: Dynamics of beta-arrestin1 protein and mRNA levels elevation by antidepressant in mononuclear leukocytes of patients with depression. Affective dis. Vol. 88; pp. 307-312, 2005. 

 

Matuzany-Ruban, A, Schreiber, G, Farkash, P, Avissar, S.: Phosducin-like protein levels in leukocytes of patients with major depression and in rat cortex: the effect of chronic treatment with antidepressants. Psychiatry Res. Vol. 141(3); pp. 287-94, 2006. 

 

Zlotnik, A, Gurevich, B, Cherniavsky, E, Tkachov, SMatuzani-Ruban, A, Leon, A., Shapira, Y. and Teichberg, V.: The contribution of the blood glutamate scavenging activity of pyruvate to its neuroprotective properties in a rat model of closed head injure. Neurochem Res. Vol. 33(6); pp. 1044-50, 2008.

 

Marosi, M, Fuzik, J, Nagy, D, Rákos, G, Kis, Z, Vécsei, L, Toldi, J, Ruban-Matuzani, A, Teichberg, VI, Farkas, T.: Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion. Eur J Pharmacol. Vol. 604(1-3); pp. 51-7, 2009

 

Matuzany-Ruban, A, Golan, M, Miroshnik, N, Schreiber, G, Avissar, S.: Normalization of GRK2 protein and mRNA measures in patients with depression predict response to antidepressants. Int J Neuropsychopharmacol. Vol. 29; pp. 83-91, 2009.

 

Ruban, A, Berkutzki T, Cooper I, Mohar B. and Teichberg, Vivian, I.: Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted glioma. Invest New Drugs. Vol. 30(6); pp. 2226-35, 2012.

 

Pérez-Mato, M, Ramos-Cabrer, P, Sobrino T, Blanco, M, Ruban, A, Mirelman, D, Menendez, P, Castillo, J, Campos, F.: Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia. Cell Death Dis. Vol. 9; 5:e992, 2014.

 

Ruban, A, Mohar, B, Jona, G, Teichberg, VI.: Blood glutamate scavenging as a novel neuroprotective treatment for paraoxon intoxication. J Cereb Blood Flow Metab. Vol. 34(2); pp. 1-7, 2014.

 

Schwartz-Arad, D, Ofec, R, Eliyahu, G, Ruban, A, Sterer, N.: Long Term Follow-Up of Dental Implants Placed in Autologous Onlay Bone Graft.  Clin Implant Dent Rel Res. doi: 10.1111/cid.12288; 2014. 

 

Ruban, A, Biton, I, Markovich, A. and Mirelman, D.: MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures. Int. J. Mol. Sci. Vol. 16 (2); pp. 3226-36, 2015. 

 

Ruban, A, Cohen-Kashi Malina K, Cooper I, Graubardt N, Babakin L, Jona G, and Teichberg V. Combined treatment of an ALS rat model with recombinant GOT1 and Oxaloacetic acid: a novel neuroprotective treatment. Neurodegen Dis. 2015. 

 

Schwartz-Arad, D, Ofec, R, Eliyahu, G, Sterer, N, Ruban, A. Onlay Bone Graft augmentation for the Treatment of Maxillary Atrophy: Implants long term follow-up (up to 131 months). J Cosmetic Dentistry Vol. 31(3); pp 76-93, 2015. 

 

Goldshmit A, Jona G, Schmuklerd E, Solomond S, Pinkas-Kramarskid R and Ruban A. Blood Glutamate Scavenger as a novel neuroprotective treatment in spinal cord injury. J Neurotrauma Mar 1. doi: 10.1089/neu.2017.5524, 2018.

 

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