פרופ' ישראל אלי לב

בי"ס ללימודי המשך ברפואה
בי"ס ללימודי המשך ברפואה
טלפון פנימי: 2251
פקס: 03-9372460

קורות חיים

EDUCATION:

 

1983-1989                   Medical School - Sackler Faculty of Medicine,

                                    Tel-Aviv University, Israel - M.D

 

1989- 1990                  Rotating Internship, Tel-Aviv Medical Center, Israel

 

1996-1999                   Residency Internal Medicine, Tel-Aviv Medical Center                                     Certified in Internal Medicine (Israel) - 2000

 

1999-2000                   Research Fellowship - Thrombosis and platelets

                                    Cardiiovascular Research Institute, Mount Sinai Medical

Center, NY, NY

                                   

2000-2003                   Fellowship in Cardiology, Department Of Cardiology,                                       Rabin Medical Center, Certified in Cardiology (Israel) - 2003

                                   

2003-2005                   Interventional Cardiology Fellowship (Clinical + research program) Baylor College of Medicine and the Methodist DeBakey Heart Center, Houston, TX, USA       

 

2006                            Assistant Professor, Weill Medical College, Cornell University, NY, and the Methodist Hospital Research  Institute, Houston, TX

 

2011                            Associate Professor of Cardiology, Sackler Faculty of Medicine, Tel-Aviv University

 

 

Academic and Other Positions:

 

Associate Professor of Cardiology, Sackler Faculty of Medicine, Tel-Aviv University

 

Director, Interventional Cardiology Unit, Hasharon Hosp., Rabin Medical Center, Israel

 

Secretary of the Interventional Cardiology Working Group, Israeli Heart Society

 

תחומי מחקר

Research Areas:

Anti-platelet and anti-thrombotic medications in the setting of percutaneous coronary interventions and acute coronary syndromes. These research areas include novel anti-platelet drugs, and response to anti-platelet medications.

Study of endothelial progenitor cells (EPCs), pertaining to repair of vascular injury, and interactions with platelets. In addition research of factors affecting levels and function of EPCs in patients with cardiovascular diseases.

פרסומים

List of original publications 2008-2013

 

1. Lev EI, Kornowski R, Vaknin-Assa H, Brosh D, Battler A, Fuchs S, Assali A. Effect of Clopidogrel Pretreatment on TIMI Perfusion grade and Clinical Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction.  Am J Cardiol 2008; 101(4):435-9

 

2. Porter A, Assali AR, Zahalka A, Iakobishvili Z, Brosh D, Lev EI, Mager A, Battler A, Kornowski R, Hasdai D. Impaired fasting glucose and outcomes of ST-elevation acute coronary syndrome treated with primary percutaneous intervention among patients without previously known diabetes mellitus. Am Heart J. 2008; 155(2):284-9.      

 

3. Lev EI, Kornowski R, Vaknin-Assa H, Porter A, Teplitsky I, Ben-Dor I, Brosh D, Fuchs S, Battler A, Assali A. Comparison of the predictive value of four different risk scores for outcomes of patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2008; 102(1):6-11.     

 

4. Guthikonda S, Mangalpally K, Vaduganathan M, Patel R, Delao T, Bergeron AL, Dong JF, Lev EI, Kleiman NS. Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy. Thromb Haemost. 2008; 100(1):83-9. 

 

5. Garg R, Tellez A, Alviar C, Granada J, Kleiman NS, Lev EI. The effect of percutaneous coronary intervention on inflammatory response and endothelial progenitor cell recruitment. Catheter Cardiovasc Interv. 2008; 72(2):205-9.

 

6. Guthikonda S, Alviar CL, Vaduganathan M, Arikan M, Tellez A, DeLao T, Granada JF, Dong JF, Kleiman NS, Lev EI. Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease.  J Am Coll Cardiol. 2008; 52(9):743-9.          

 

7. Kornowski R, Vaknin-Assa H, Lev E, Ben-Dor I, Teplitsky I, Rechavia E, Brosh D, Fuchs S, Assali A. Clinical results of drug eluting stents compared to bare metal stents for patients with ST elevation acute myocardial infarction. Acute Card Care. 2008;10(3):167-72

 

8. Uretsky BF, Birnbaum Y, Osman A, Gupta R, Paniagua O, Chamoun A, Pohwani A, Lui C, Lev E, McGehee T, Kumar D, Akhtar A, Anzuini A, Schwarz ER, Wang FW. Distal myocardial protection with intracoronary beta blocker when added to a Gp IIb/IIIa platelet receptor blocker during percutaneous coronary intervention improves clinical outcome. Catheter Cardiovasc Interv. 2008; 72(4):488-97.      

 

9. Vaduganathan M, Alviar CL, Arikan ME, Tellez A, Guthikonda S, DeLao T, Granada JF, Kleiman NS, Ballantyne CM, Lev EI. Platelet reactivity and response to aspirin in subjects with the metabolic syndrome.  Am Heart J. 2008; 156(5):1002.e1-1002.e7.  

 

10. Lev EI, Kornowski R, Vaknin-Assa H, Ben-Dor I, Brosh D, Teplitsky I, Fuchs S, Battler A, Assali A. Effect of previous treatment with statins on outcome of patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Am J Cardiol. 2009;103(2):165-9                              

 

11. Fuchs S, Kornowski R, Teplitsky I, Brosh D, Lev E, Vaknin-Assa H, Ben-Dor I, Iakobishvili Z, Rechavia E, Battler A, Assali A. Major bleeding complicating contemporary primary percutaneous coronary interventions-incidence, predictors, and prognostic implications. Cardiovasc Revasc Med. 2009; 10(2):88-93. 

 

12. Bouganim T, Shapira Y, Sagie A, Vaturi M, Battler A, Kornowski R, Lev EI. Platelet Reactivity in Patients with a History of Obstructive Prosthetic Valve Thrombosis.  Am J Cardiol. 2009; 103(12):1760-3                                       

 

13. Ben-Dor I, Vaknin-Assa H, Lev E, Brosh D, Fuchs S, Assali A, Kornowski R. Clinical results of unprotected left main coronary stenting. Isr Med Assoc J. 2009; 11(3):154-9. 

 

14. Kornowski R, Vaknin-Assa H, Ukabi S, Lev EI, Assali A. PRO-Kinetic: results from an "all-comers" single centre clinical experience. EuroIntervention. 2009; 5(1):109-14.  

                         

15. Assali A, Vaknin-Assa H, Lev E, Bental T, Ben-Dor I, Teplitsky I, Brosh D, Fuchs S, Eidelman L, Battler A, Kornowski R. The risk of cardiac complications following noncardiac surgery in patients with drug eluting stents implanted at least six months before surgery. Catheter Cardiovasc Interv. 2009; 74:837–843.                

 

16. Mager A, Orvin K, Koren-Morag N, Lev IE, Assali A, Kornowski R, Shohat M, Battler A, Hasdai D. Impact of homocysteine-lowering vitamin therapy on long-term outcome of patients with coronary artery disease. Am J Cardiol. 2009; 104(6):745-9.

 

17.  Granada JF, Alviar CL, Wallace-Bradley D, Osteen M, Dave B, Tellez A, Win HK, Kleiman NS, Kaluza GL, Lev EI. Patterns of activation and deposition of platelets exposed to the polymeric surface of the paclitaxel eluting stent. J Thromb Thrombolysis. 2010;29(1):60-9

      

18.  Lev EI, Solodky A, Harel N, Mager A, Brosh D, Assali A, Roller M, Battler A, Kleiman N, Kornowski R. Treatment of aspirin resistant patients with omega-3 fatty acids vs. aspirin dose escalation.  J Am Coll Cardiol. 2010; 12;55(2):114-21 

 

19.  Greenberg G, Assali A, Vaknin-Assa H, Brosh D, Teplitsky I, Fuchs S, Battler A,  Kornowski R, Lev EI. Hematocrit level as a marker of outcome in ST-segment elevation myocardial infarction.  Am J Cardiol 2010; 105(4):435-40            

 

20.  Messika AH, Kaluski DN, Lev E, Iakobishvili Z, Shohat M, Hasdai D, Mager A. Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes. Eur J Cardiovasc Prev Rehabil. 2010: 17(6):701-5                                             

 

21.  Bental T, Assali A, Vaknin-Assa A, Lev EI, Brosh D, Fuchs S, Battler A, Kornowski R. A comparative analysis of major clinical outcomes using drug-eluting stents versus bare-metal stents in a large consecutive patient cohort. Catheter Cardiovasc Interv 2010: 76(3):374-80.

      

22. Vaknin-Assa H, Assali A, Lev EI, Ben-Dor I, Brosh D, Teplitsky I, Kornowski R.  Characterization and Clinical Outcomes of Drug-Eluting In-Stent Restenosis. Isr Med Assoc J  2010; 12: 273–276.     

 

23.  Lev EI, Leshem-Lev D, Mager A, Vaknin H, Harel N, Zimra Y, Bental T, Greenberg G, Dvir D, Assali A, Battler A, Kornowski R. Circulating endothelial progenitor cells levels and function in patients who experienced late coronary stent thrombosis. European Heart Journal 2010: 31(21):2625-32            

 

24. Vaknin-Assa H, Assali A, Lev EI, Ukabi S, Bental T, Kornowski R. Failure of Drug Eluting Stents Presented as Definite Stent Thrombosis. Catheter Cardiovasc Interv 2010; 76:93–97

     

25.  Hamdan A, Kornowski R, Lev EI, Sagie A, Fuchs S, Brosh D, Battler A, Assali AR. Impact of myocardial blush on left ventricular remodeling after first anterior myocardial infarction treated successfully with primary coronary intervention. Isr Med Assoc J. 2010;12:211-5.

 

26. Leshem-Lev D, Omelchenko A, Perl L, Kornowski R, Battler A, Lev EI. Exposure to platelets promotes functional properties of endothelial progenitor cells. J Thromb Thrombolysis  2010: 30(4):398-403

      

27.  Dvir D, Assali A, Lev E, Ben Dor I, Battler A, Kornowski R. Percutaneous interventions in unprotected left main lesions: novel three-dimensional imaging and quantitative analysis before and after intervention. Cardiovasc Revasc Med 2010: 11(4):236-40         

28.  Mager A, Assa HV, Lev EI, Bental T, Assali A, Kornowski R. The ratio of contrast volume to glomerular filtration rate predicts outcomes after percutaneous coronary intervention for ST-segment elevation acute myocardial infarction. Catheter Cardiovasc Interv. 2011; 78(2):198-201

 

29. Vaturi M, Perl L, Leshem-Lev D, Dadush O, Bental T, Shapira Y, Yedidya I, Greenberg G, Kornowski R, Sagie A, Battler A, Lev EI. Circulating endothelial progenitor cells in patients with dysfunctional vs. normally functioning congenitally bicuspid aortic valves. Am J Cardiol. 2011; 108(2):272-6

      

30.  Minha S, Bental T, Assali A, Vaknin-Assa H, Lev EI, Rechavia E, Battler A, Kornowski R. A comparative analysis of major clinical outcomes using drug-eluting stents versus bare metal stents in diabetic versus non-diabetic Patients. Catheter Cardiovasc Interv. 2011; 78(5):710-7                                                               

 

31. Wara AK, Foo S, Croce K, Sun X, Icli B, Tesmenitsky Y, Esen F, Lee JS, Subramaniam M, Spelsberg TC, Lev EI, Leshem-Lev D, Pande RL, Creager MA, Rosenzweig A, Feinberg MW. TGF-{beta}1 signaling and Kruppel-like factor 10 regulate bone marrow-derived pro-angiogenic cell differentiation, function, and neovascularization. Blood. 2011; 118(24):6450-60                     

 

32. Yedidya I, Netzer A, Vaduganathan M, Solodky A, Kornowski R, Lev EI. Clopidogrel tapering as a strategy to attenuate platelet rebound phenomenon in patients with bare-metal stents. J Thromb Thrombolysis. 2012; 33(1):16-21  

33.  Assali AR, Vaknin-Assa H, Lev E, Teplitsky I, Dvir D, Brosh D, Bental T, Battler A, Kornowski R. Drug Eluting Stenting in Bifurcation Coronary Lesions Long-Term Results Applying a Systematic Treatment Strategy. Catheter Cardiovasc Interv. 2012; 79(4):615-22                                                                            

34. Kornowski R, Vaknin-Assa H, Assali A, Lev EI, Porter A, Battler A, Bental T. A comparative analysis of major clinical outcomes with drug-eluting stents versus bare metal stents in male versus female patients. EuroIntervention. 2012; 7(9):1051-9 

35. Alviar CL, Tellez A, Wang M, Potts P, Smith D, Tsui M, Budzynski W, Raizner AE, Kleiman NS, Lev EI, Granada JF, Kaluza GL. Low-dose sirolimus-eluting hydroxyapatite coating on stents does not increase platelet activation and adhesion ex vivo. J Thromb Thrombolysis. 2012; 34(1):91-8                           

36. Assali A, Vaduganathan M, Vaknin-Assa H, Lev EI, Brosh D, Teplitsky I, Bental T, Battler A, Kornowski R. Comparison of late (3-year) registry data outcomes using bare metal versus drug-eluting stents for treating ST-segment elevation acute myocardial infarctions. Am J Cardiol. 2012; 109(11):1563-8.                            

37. Issan Y, Hochhauser E, Kornowski R, Leshem-Lev D, Lev E, Sharoni R, Vanella L, Puri N, Laniado-Schwartzman M, Abraham NG, Porat E. Endothelial Progenitor Cell Function Inversely Correlates With Long-term Glucose Control in Diabetic Patients: Association With the Attenuation of the Heme Oxygenase-Adiponectin Axis. Can J Cardiol. 2012 Mar 23                                                            

38. Minha S, Kornowski R, Vaknin-Assa H, Dvir D, Rechavia E, Teplitsky I, Brosh D, Bental T, Shor N, Battler A, Lev E, Assali A. The impact of intracoronary thrombus aspiration on STEMI outcomes.

39. Solomon A, Blum A, Peleg A, Lev EI, Leshem-Lev D, Hasin Y. Endothelial progenitor cells are suppressed in anemic patients with acute coronary syndrome. Am J Med. 2012; 125(6):604-11                                                 

40. Codner P, Vaduganathan M, Rechavia E, Iakobishvili Z, Greenberg G, Assali A, Hasdai D, Battler A, Kornowski R, Lev EI. Clopidogrel Response Up to Six Months After Acute Myocardial Infarction. Am J Cardiol. 2012; 110(3):321-5               

41. Perl L, Netzer A, Rechavia E, Bental T, Assali A, Codner P, Mager A, Battler A, Kornowski R, Lev EI. Long-Term Outcome of Patients with Antiphospholipid Syndrome Who Undergo Percutaneous Coronary Intervention. Cardiology. 2012; 122(2):76-82                                                                                           

42. Greenberg G, Assali A, Assa-Vaknin H, Brosh D, Teplitsky I, Battler A, Kornowski R, Lev EI. Outcome of Patients Presenting with ST Elevation Myocardial Infarct and Cardiogenic Shock: A Contemporary Single Center's Experience. Cardiology. 2012; 122(2):83-88                                                                                            

43. Eisen A, Bental T, Assali A, Kornowski R, Lev EI. Mean platelet volume as a predictor for long-term outcome after percutaneous coronary intervention. J Thromb Thrombolysis. 2013 Jan                                                                           

44. Farkouh ME, Domanski M, Sleeper LA, et al; FREEDOM Trial Investigators. Strategies for multivessel revascularization in patients with diabetes. N Engl J Med. 2012; 367(25):2375-84.

45. Issan Y, Hochhauser E, Guo A, Gotlinger KH, Kornowski R, Leshem-Lev D, Lev E, Porat E, Snir E, Thompson CI, Abraham NG, Laniado-Schwartzman M. Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia. Prostaglandins Other Lipid Mediat. 2013; 100-101C:15-21

46. Vaturi M, Vaduganathan M, Bental T, Solodky A, Kornowski R, Lev EI. Relation of Aspirin Response to Age in Patients With Stable Coronary Artery Disease. Am J Cardiol. 2013 Apr                                                                                             

47. Lev EI, Singer J, Leshem-Lev D, Rigler M, Dadush O, Vaduganathan M, Battler A, Kornowski R. Effect of intensive glycaemic control on endothelial progenitor cells in patients with long-standing uncontrolled type 2 diabetes. Eur J Prev Cardiol. 2013 Apr.           

 

Grants (2008-2012):

 

2008                Keren Keisaria (Keisaria Fund) research grant (100,000$). Project Title: Endothelial Progenitor Cell and Platelet Function and Interaction in Patients with Diabetes: the Effect of Intensive Glycemic Control. Principal - investigator

 

2008                The Dr. Herman Schauder research grant, Tel-Aviv University (10,000$). Project title: Endothelial Progenitor Cells Function and Number in Patients with Coronary Stent Thrombosis. Principal investigator.

 

2010                The Schauder grant for research, Tel-Aviv University (10,000$). Project title: Endothelial Progenitor Cells Function and Level in Patients with Bicuspid Aortic Valves. Principal - investigator

 

2010                Grant by the Israel Ministry of Health, Chief Scientist Office ("Madan Harashi") (30,000 NIS = 8,000$). Project title: Level and function of endothelial progenitor cells in patients with a bicuspid aortic valve". Principal – investigator

 

 2012               Grant for research, Tel-Aviv University (10,000$). Project title: Effect of High Dose Statin Pretreatment on Endothelial Progenitor Cells and Circulating Endothelial Cells after Percutaneous Coronary Intervention. Principal - investigator    

 

אוניברסיטת תל אביב עושה כל מאמץ לכבד זכויות יוצרים. אם בבעלותך זכויות יוצרים בתכנים שנמצאים פה ו/או השימוש
שנעשה בתכנים אלה לדעתך מפר זכויות, נא לפנות בהקדם לכתובת שכאן >>