Education
1984 M.D. Tel Aviv University
1995 Ophthalmology Tel Aviv University
2000 Fellowship in Vitreo-retinal Surgery University of California, Davis
Academic and other positions
Head of the Vitreo-retinal Surgery Unit, Dept. of Ophthalmology, Tel Aviv Medical Center
Senior Lecturer, Sackler Faculty of Medicine, Tel Aviv University
Research areas
At the Eye Research Unit (ERU) at TASMC I am leading the research team involved in the development of, as well as in conducting studies of new techniques and devices for vitreo-retinal surgery. I am primarily interested in investigating new lines of treatment of retinal pathologies.
• Mesenchymal stem cell differentiation into retinal and sub retinal components and implantations such cells into retinal tissue.
• Development of retinal chip implant.
• Small interfering RNA (siRNA) in patients with DME
List of publications (2008-2012)
Schwartz S, George J, Ben-Shoshan J, Luboshits G, Avni I, Levkovitch-Verbin H, Ziv H, Rosner M, Barak A. Drug Modification of Angiogenesis in a Rat Cornea Model. Invest. Ophthalmol. Vis. Sci. 2008 49: 250-254.
Ben-Shoshan J, Schwartz S, Luboshits G, Maysel-Auslender S, Barzelay A, Polak-Charcon S, Tzahor E, Barshack I, Barak A, Levkovitch-Verbin H, Keren G, George J.
Constitutive Expression of HIF-1
and HIF-2in Bone Marrow Stromal Cells Differentially Promote their Pro-angiogenic Properties. Stem Cells 2008 Oct;26(10):2634-43. Epub 2008 Aug 7.
Adiel Barak, Jacob George, Anat Lowenstein, Michaella Goldstein, Haim Shmlovich, and Arnon Afek. Fewer Circulating Endothelial Progenitor Cells in Newly Diagnosed Neovascular AMD Patients. The Open Tissue Engineering and Regenerative Medicine
Journal, 2009, 2, 48-52
Burgansky-Eliash Z, Nelson DA, Bar-Tal OP, Lowenstein A, Grinvald A, Barak A. Reduced retinal blood flow velocity in diabetic retinopathy. Retina. 2010 May;30(5):765-73.
Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Yoon YH, Jacques ML, Jiao J, Li XY, Whitcup SM; OZURDEX GENEVA Study Group (Barak A). Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology. 2010 Jun;117(6):1134-1146.e3. Epub 2010 Apr 24.
Barzelay A, Lowenstein A, George J, Barak A. Influence of non-toxic doses of bevacizumab and ranibizumab on endothelial functions and inhibition of angiogenesis. Current Eye Research. 2010 Sep;35(9):835-41.
Neudorfer M, Oren N, Barak A. High-frequency ultrasound biomicroscopy of the anterior segment morphometry before and immediately after pars plana vitrectomy. Eur J Ophthalmol. 2011 Mar-Apr;21(2):173-8.
Mezad-Koursh D, Goldstein M, Heilwail G, Zayit-Soudry S, Loewenstein A, Barak A. Clinical characteristics of endophthalmitis after an injection of intravitreal antivascular endothelial growth factor. Retina. 2010 Jul-Aug;30(7):1051-7.
Adiel Barak (editor). Vitreous and VItreo-retinal disorders: Section 8 P596. In: Clinical Eye Atlas. 2nd Edition. Edited by Daniel Gold and Richard Lewis. Oxford University Press, 2010.
Neudorfer M, Waisbourd M, Anteby I, Liran A, Goldenberg D, Barak A, Kessler A. Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases. Oncol Rep. 2011 Jan;25(1):91-6.
Moisseiev E, Kinori M, Glovinsky Y, Loewenstein A, Moisseiev J, Barak A. Retained lens fragments: nucleus fragments are associated with worse prognosis than cortex or epinucleus fragments. Eur J Ophthalmol. 2011 Mar 24. pii:. doi: 10.5301/EJO.2011.6483. [Epub ahead of print].
Spierer O, Siminovsky Z, Loewenstein A, Barak A. Outcomes of 20-gauge transconjunctival sutureless vitrectomy. Retina. 2011 May 20. [Epub ahead of print].
Barak A, Elhalel A, Pikkel J, Krauss E, Miller B. Incidence and severity of ocular and adnexal injuries during the Second Lebanon War among Israeli soldiers and civilians. Graefes Arch Clin Exp Ophthalmol. 2011 Apr 12. [Epub ahead of print].
Moisseiev E, Davidovitch Z, Loewenstein A, Barak A. Outcomes of epiretinal membrane removal in eyes with and without concurrent vision-limiting ocular disease. Ophthalmologica. 2011;226(2):71-5. Epub 2011 May 25.
Kinori M, Moisseiev E, Shoshany N, Fabian ID, Skaat A, Barak A, Loewenstein A, Moisseiev J. Comparison of pars plana vitrectomy with and without scleral buckle for the repair of primary rhegmatogenous retinal detachment. Am J Ophthalmol. 2011 Aug;152(2):291-297.e2. Epub 2011 Jun 12.
Fabian ID, Moisseiev E, Moisseiev J, Moroz I, Barak A, Alhalel A. Macular hole after vitrectomy for primary rhegmatogenous retinal detachment. Retina. 2011 Jul 26. [Epub ahead of print].
Zayit-Soudry S, Zemel E, Barak A, Perlman I, Loewenstein A. Safety of intravitreal bevacizumab in the developing rabbit retina. Retina. 2011 Oct;31(9):1885-95
Barak A, Burgansky-Eliash Z, Barash H, Nelson DA, Grinvald A, Loewenstein A. The effect of intravitreal bevacizumab (Avastin) injection on retinal blood flow velocity in patients with choroidal neovascularization. Eur J Ophthalmol. 2011Nov 7:0. doi: 10.5301/ejo.5000074. [Epub ahead of print] PubMed PMID: 22081670.
Moisseiev E, Davidovitch Z, Kinori M, Loewenstein A, Moisseiev J, Barak A. Vitrectomy for idiopathic epiretinal membrane in elderly patients: surgical outcomes and visual prognosis. Curr Eye Res. 2012 Jan;37(1):50-4. Epub 2011 Oct 11. PubMed PMID: 21988485.
Nelson DA, Burgansky-Eliash Z, Barash H, Loewenstein A, Barak A, Bartov E, Rock T, Grinvald A. High-resolution wide-field imaging of perfused capillaries without the use of contrast agent. Clin Ophthalmol. 2011;5:1095-106. Epub 2011 Aug 9. PubMed PMID: 21887088; PubMed Central PMCID: PMC3162286.
Burgansky-Eliash Z, Barak A, Barash H, Nelson DA, Pupko O, Lowenstein A[sic], Grinvald A, Rubinstein A. Increased retinal blood flow velocity in patients with early diabetes mellitus. Retina. 2012 Jan;32(1):112-9. PubMed PMID: 21878846.
Moisseiev E, Barak A. Toxic anterior segment syndrome outbreak after vitrectomy and silicone oil injection. Eur J Ophthalmol. 2012 Feb 6:0. doi: 10.5301/ejo.5000116. [Epub ahead of print] PMID: 22328306
Julia A. Haller, MD,Francesco Bandello, MD, Rubens Belfort Jr, MD, Mark S. Blumenkranz, MD, Mark Gillies, MD, Jeffrey Heier, MD, Anat Loewenstein, MD, Young Hee Yoon, MD, Jenny Jiao, PhD, Xiao-Yan Li, MD, Scott M. Whitcup, MD, for the Ozurdex GENEVA Study Group*. Dexamethasone Intravitreal Implant in Patients with Macular Edema Related to Branch or Central Retinal Vein Occlusion. Ophthalmology. 2011 Dec;118(12):2453-60. Epub 2011 Jul 20.
Dugel PU, Petrarca R, Bennett M, Barak A, Weinberger D, Nau J, Jackson TL. Macular Epiretinal Brachytherapy in Treated Age-Related Macular Degeneration: MERITAGE Study: Twelve-Month Safety and Efficacy Results. Ophthalmology. 2012 Mar 30. [Epub ahead of print].
Neudorfer M, Weinberg A, Loewenstein A, Barak A. Differential Optical Density of Subretinal Spaces. Invest Ophthalmol Vis Sci. 2012 Apr 12. [Epub ahead of print]
Hadas Newman, Shiran Shapira, Oriel Spierer, Sarah Kraus, Mordechai Rosner, Sarah Pri-Chen, , Anat Loewenstein, Nadir Arber, Adiel Barak. Involvement of CD24 in Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy. Current Eye Research. 2012 Jun;37(6):532-9.
Goldenberg D, Moisseiev E, Goldstein M, Loewenstein A, Barak A. Enhanced Depth Imaging Optical Coherence Tomography: Choroidal Thickness and Correlations With Age, Refractive Error, and Axial Length. Ophthalmic Surg Lasers Imaging. 2012 May 3:1-6. [Epub ahead of print]
Moisseiev E, Regenbogen M, Bartfeld Y, Barak A. Evaluation of pain in intravitreal bevacizumab injections. Curr Eye Res. 2012 Sep;37(9):813-7. doi: 10.3109/02713683.2012.681335. Epub 2012 Jun 5.
Neudorfer M, Waisbourd M, Buzi S, Wygnanski-Jaffe T, Stolovitch C, Barak A, Goldenberg D, Kessler A. Color Doppler imaging of eyes with persistent fetal vasculature. Pediatr Radiol. 2012 Oct;42(10):1229-34. doi: 10.1007/s00247-012-2432-0. Epub 2012 Jun 16.
Burgansky-Eliash Z, Lowenstein A, Neuderfer M, Kesler A, Barash H, Nelson DA, Grinvald A, Barak A. The Correlation Between Retinal Blood Flow Velocity Measured by the Retinal Function Imager and Various Physiological Parameters. Ophthalmic Surg Lasers Imaging. 2012 Aug 10:1-8. doi: 10.3928/15428877-20120802-01.
Moisseiev E, Ohana O, Gershovitch L, Barak A. Visual prognosis and complications following silicone oil removal. Eur J Ophthalmol. 2012 Oct 4:0. doi: 10.5301/ejo.5000199.
Moisseiev E, Goldstein M, Waisbourd M, Barak A, Loewenstein A. Long-term evaluation of patients treated with dexamethasone intravitreal implant for macular edema due to retinal vein occlusion. Eye (Lond). 2012 Nov 16. doi: 10.1038/eye.2012.226.
Dugel PU, Bebchuk JD, Nau J, Reichel E, Singer M, Barak A, Binder S, Jackson TL; CABERNET Study Group. Epimacular Brachytherapy for Neovascular Age-Related Macular Degeneration: A Randomized, Controlled Trial (CABERNET). Ophthalmology. 2012 Nov 19. doi:pii: S0161-6420(12)00722-1. 10.1016/j.ophtha.2012.07.068.
