פרופ' שמואל בנאי

קרדיולוגיה סגל אקדמי קליני
ניווט מהיר:

קורות חיים

Education:
1973 - 1979 The Hebrew University Hadassah Medical School, Jerusalem, Israel - M.D.
1978 The Mount Sinai Hospital, New York, NY, USA - elective studies in Cardiology and Pulmonology
1979 Bikur-Cholim Hospital, Jerusalem, Israel, Department of Cardiology, clinical research: Precordial Electrocardiographic Mapping in patients with acute myocardial infarction - M.D. thesis
1979 - 1980 Rotating Internship, Soroka Medical Center, Beer Sheva, Israel
1980 - 1984 Military Service, Medical Officer, Captain, Fighting Armored Brigade, IDF
1984 - 1986 Residency, Department of Internal Medicine, Bikur-Cholim Hospital, Jerusalem, Israel

1986 - 1988 Cardiology Fellowship, Department of Cardiology, Bikur-Cholim Hospital, Jerusalem, Israel
1988 - 1991 National Institutes of Health, National Heart, Lung and Blood Institute, Cardiology Branch, Section of Experimental Physiology and Pharmacology, Bethesda, Maryland, USA - post doctoral basic research in Cardiology

 

Professional and Academic Appointments:
1988 - 1991 Visiting Associate, post-doctoral research, National Institutes of Health, National Heart, Lung and Blood Institute, Cardiology Branch, Section of Experimental Physiology and Pharmacology, Bethesda, Maryland, USA
1990 - 1991 Medical Staff, Department of Medicine and Critical Care, Doctor's Community Hospital of Prince George's County, Lanham, Maryland, USA
1991- 2004 Senior Cardiologist, Cardiology Department, Bikur-Cholim Hospital, Jerusalem
1992 Adjunct Lecturer in Medicine (Cardiology). The Hebrew
University- Hadassah Medical School, Jerusalem, Israel
1995 Adjunct Senior Lecturer in Medicine (Cardiology). The Hebrew University - Hadassah Medical School, Jerusalem, Israel
1996-2004 Director, Interventional Cardiology Unit, Cardiology Department, Bikur -Cholim Hospital, Jerusalem
1997-1998 Associate Hospital Director, Bikur-Cholim Hospital, Jerusalem
1999-2004 Associate Director, Department of Cardiology, Bikur-Cholim Hospital, Jerusalem
2002-2005 Chief Medical Officer, Neovasc Inc.
2002 Associate Professor of Medicine and Cardiology. The Hebrew University, Jerusalem, Israel
2003-2010 Chief Scientific Editor, Interventional Cardiology, e-med, Internet Medical News Channel
2005-2007 Chief Scientific Editor, Medicine Heart Journal
2004-2005 Senior Cardiologist, Director, Medical Unit, The Heart Institute, Hadassah University Hospital, Jerusalem
2005-2009 Medical Director, Neovasc Medical
2009-present Medical Director, Neovasc Inc
2006-present Director, Interventional Cardiology, Division of Cardiology, The Tel Aviv Souraski Medical Center, Tel Aviv, Israel
2006-2008 Chief Medical Officer, Innovea Medical
2007-2012 Member of the Board of Directors, ITGI Medical
April 2007 Associate Professor of Cardiology. Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel
2011-present Medical consultant and PI, ByPass Ltd.
2012-present Scientific Advisory Board, Arineta Cardio Imaging

 

פרסומים

PUBLICATIONS
Papers in peer-reviewed journals
a. Original research papers
1. Banai S, Tzivoni D:
Ambulatory ECG monitoring in patients recovering from acute myocardial infarction Harefuah 111:79-82;1986 (Hebrew)
2. Tzivoni D, Gavish A, Banai S, Benhorin J, Stern S:
Ambulatory electrocardiographic monitoring foe evaluation of antianginal therapy.
Practical Cardiology 13:41-48;1987
3. Tzivoni D, Banai S, Keren A:
Magnesium Sulfate: a new mode of therapy for Torsade de Pointes.
Arrhythmia Clinic, (supplement to Practical Cardiology), 1:12-15;1986
4. Tzivoni D, Schuger C, Banai S:
Holter monitoring for ambulatory detection and treatment of ventricular arrhythmias: Uses and limitations.
Cardiovascular Clinics, 18:61-77;1988
5. Tzivoni D, Banai S, Schuger C, Benhorin J, Keren A, Gottlieb S, Stern S: Magnesium Sulphate: A new therapy for Torsade de Pointes.
Circulation 77:392-397;1988
6. Tzivoni D, Gavish A, Benhorin J, Banai S, Keren A, Stern S:
Day to day variability of myocardial ischemic episodes in coronary artery disease.
Am J Cardiol 60:1003-1005;1987
7. Tzivoni D, Gavish A, Zin D, Gottlieb S, Moriel M, Keren A, Banai S, Stern S: Prognostic significance of ischemic episodes in patients with previous myocardial infarction.
Am J Cardiol 62:661-664;1988
8. Banai S, Benhorin J, Stern S, Tzivoni D:
Effect of nisoldipine on myocardial ischemia during daily activities: A preliminary report.
Isr J Med Sci 25:524-527;1989
Shmuel Banai, M.D.
April 2013
2
9. Stern S, Banai S, Keren A, Tzivoni D:
Ventricular ectopic activity during myocardial ischemia in ambulatory patients. Am J Cardiol 65:412-416;1990
10. Banai S, Haggroth L, Epstein S, Casscells W:
Influence of extracellular magnesium on capillary endothelial cell migration and proliferation.
Circulation Research 67:645-650;1990 (IF=9.489)
11. Banai S, Moriel M, Benhorin J, Gavish A, Stern S, Tzivoni D:
Changes in myocardial ischemic threshold during daily activities.
Am J Cardiol 66:1403-1406;1990 (IF=3.368)
12. Tzivoni D, Keren A, Banai S, Stern S:
Terminology of torsade de pointes.
Cardiovasc Drug Ther 5:505-508;1991
13. Tzivoni D, Banai S, Botvin S, Zilberman A, Weisz TA, Gavish A, Medina A, Benhorin J, Rogel S, Caspi A, Stern S:
Effects of nisoldipine on myocardial ischemia during exercise and during daily activity.
Am J Cardiol 67:559-564;1991 (IF=3.368)
14. Benhorin J, Moriel M, Gavish A, Medina A, Banai S, Shapira M, Stern S, Tzivoni D: Usefulness of severity of ischemia on exercise testing in predicting the severity of myocardial ischemia during daily activities.
Am J Cardiol 68:176-180;1991 (IF=3.368)
15. Banai S, Jaklitsch MT, Casscells W, Shou M, Shrivastav S, Correa R, Epstein SE, Unger EF:
Effects of acidic fibroblast growth factor on normal and ischemic myocardium.
Circulation Research 69:76-85;1991 (IF=9.489)
16. Banai S, Shou M, Correa R, Jaklitsch MT, Douek PC, Bonner RF, Epstein SE, Unger EF:
The rabbit ear model of injury-induced arterial smooth muscle cell proliferation: kinetics, reproducibility, and implications.
Circulation Research 69:748-756;1991 (IF=9.489)
17. Douek PC, Correa R, Neville R, Unger EF, Shou M, Banai S, Ferrans V, Epstein SE, Leon MB, Bonner RF:
Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers.
Circulation, 86:1249-1256;1992 (IF=14.739)
Shmuel Banai, M.D.
April 2013
3
18. Banai S, Tzivoni D:
Drug therapy for torsade de pointed.
J of Cardiovasc Electrophysiology 4:206-210;1993 (IF=3.064)
19. Unger EF, Banai S, Shou M, Jaklitsch M, Jaye M, Epstein SE:
A model to assess interventions to improve collateral blood flow: continuous administration of agents into the left coronary artery of dogs.
Cardiovascular Research: 27:785-791;1993 (IF=6.064)
20. Benhorin J, Banai S, Moriel M, Gavish A, Keren A, Stern S, Tzivoni D:
Circadian variations in ischemic threshold and their relation to the occurrence of ischemic episodes.
Circulation 87:808-814;1993 (IF=14.739)
21. Unger EF, Banai S, Shou M, Lazarous D, Jaklitsch MT, Scheinowitz M, Correa R, Klingbeil C, Epstein SE:
Basic Fibroblast Growth Factor Accelerates Myocardial Angiogenesis in a Canine Model.
American Journal of Physiology 1994;266:H1588-H1595 (IF=3.708)
22. Banai S, Jaklitsch MT, Shou M, Lazarous D, Scheinowitz M, Biro S, Epstein SE, Unger EF:
Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.
Circulation,1994;89:2183-2189 (IF=14.739)
23. Banai S, Shweiki D, Chandra M, Lazarovici G, Keshet E:
Upregulation of Vascular Endothelial Growth Factor Expression Induced by Myocardial Ischemia: Implications for Coronary Angiogenesis.
Cardiovascular Research 1994;28:1176-1179 (IF=6.064)
24. Gertz SD, Gimple LW, Banai S, Powers ER, Roberts WC, Perez LS, Sarembock IJ: Geometric remodeling is not the principal pathogenetic process in restenosis after angioplasty. Evidence from correlative angiographic and histomorphometric studies of atherosclerotic femoral arteries in rabbits.
Circulation 1994;90:3001-3008 (IF=14.739)
25. Scheinowitz M, Shou M, Banai S, Gertz SD, Lazarous DF, Epstein SE, Unger EF:
Neointimal proliferation in canine coronary arteries. a model of restenosis permitting local and continuous drug delivery.
Laboratory Investigation 1994;71:813-819
26. Miao HQ, Cui RY, Vlodavsky I, Banai S, Perez LS, Gertz SD:
Shmuel Banai, M.D.
April 2013
4
Model and application of arterial stenosis with smooth muscle cell proliferation induced by injury in the rabbit ear.
Chinese J Arterioscl 1995;3(1):45-48
27. Golomb G. Fishbein I, Banai S, Mishaly D, MoscovitzD, S. Gertz D, Gazit A, Levitzki A:
Controlled delivery of a tyrphostin inhibits intimal hyperplasia in a rat carotid artery injury model.
Atherosclerosis 1996;125:171-182 (IF=3.962)
28. Fishbein I, Banai S, Levitzki A, MoscovitzD, S. Gertz D, Gazit A, Golomb G:
Perivascular and intraluminal delivery systems of a tyrphostin for the treatment of restenosis.
Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 1996;23:17-18
29. Banai S, Levitzki A:
Signal Transduction pathway targeted therapy - a strategy to inhibit restenosis. Cardiology Update 1997;16:31-35
30. Banai S, Wolf Y, Golomb G, Pearle A, Waltenberger J, Schneider A, Gazit A, Perez L, Huber R, Lazarovichi G, Levitzki A, Gertz SD:
PDGF-Receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.
Circulation: 1998;97:1960-1970 (IF=14.739)
31. Gertz SD, Barry WL, Gimple LW, Banai S, Perez LS, McNamara CA, Powers ER, Ragosta M, Owens GK, Sarembock IJ:
Predictors of luminal narrowing after angioplasty in atherosclerotic rabbits. Cardiovasc Res 1998;36:396-407 (IF=6.0.64)
32. Gertz SD, Fallon JT, Gallo R, Taubman MB, Banai S, Barry WL, Gimple LW, Nemerson Y, Thiruvikraman SV, Naidu SS, Chesebro JH, Fuster V, Sarembock IJ, Badimon JJ.
Hirudin reduces tissue factor expression in the neointima after balloon injury in rabbit femoral and porcine coronary arteries.
Circulation: 1998;98:580-587 (IF=14.739)
33. Banai S, Daniel N, Keren A, Benhorin J:
ReoPro treatment in the cath lab and in the CCU.
Hrefuah 1999;136:29-34
34. Wolf Y, Gertz SD, Banai S:
Animal models in syndromes of accelerated arteriosclerosis. Annales of Vascular Surgery 1999;13:328-38
Shmuel Banai, M.D.
April 2013
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35. Lotan C, Bakst A, Rozenmam Y, Miller H, Beyar R, Pardes A, Hertz I, Tamari I, Ayzenberg O, Iliah R, Hendler A, Banai S:
Initial and long term results with the Crossflex stent – data from national registry.
Int J Cardiovasc Interven 1999;2:237-240
36. Wolf Y, Gertz SD, Banai S:
Modeles Animaux d'Atherosclerose Acceleree.
Ann Chir Vasc 1999;13:328-338
37. Fishbein I, Waltenberger J, Banai S, Rabinovich L, Chorny M, Levitzki A, Gazit A, Huber R, Gertz SD, Golomb G:
Local delivery of Platelet Derived Growth Factor Receptor-specific tyrphostin inhibits neointimal formation in rats.
Atheroscler Thromb Vasc Biol. 2000;20:667-676 (IF=6.37)
38. Fishbein I., Chorny M., Rabinovich L., Banai S., Gati I., Golomb G.:
Nanoparticulate delivery system of a tyrphostin for the treatment of restenosis,
J. Control Release 2000;65:221-229 (IF=5.732)
39. Landau E, Tirosh R, Pinson A, Banai S, Even-Ram S, Maoz M, Katzav S, Bar-Shavit R.:
Protection of thrombin receptor expression under hypoxia.
J Biol Chem. 2000:28;275(4):2281-7 (IF=5.328)
40. Banai S, Medina A, Keren A,:
Glycoprotein IIb/IIIa Receptor Antagonists in Acute MI and Primary Coronary Stenting – Not Always Effective.
Internat J Intervent Cardiol 2000;3:241-243
41. Banai S, Gertz SD,:
Tissue factor as a therapeutic target in acute and chronic coronary syndromes.
Am J Cardiol 2001;87:763-765 (IF=3.368)
42. Fishbein I, Chorny M, Banai S, Levitzki A, Danenberg HD, Gao J, Chen X, Moerman E, Gati I, Goldwasser V, Golomb G:
Formulation and delivery mode affect disposition and activity of tyrphostin- loaded nanoparticles in the rat carotid model.
Arterioscl Thrombos Vasc Biol, 2001;21:1434-1439 (IF=6.37)
43. Margolin, L., Fishbein, I., Banai, S., Golomb, G., Reich, R., Perez, L.S. and Gertz, S.D.
Metalloproteinase Inhibitor Attenuates Neointima Formation and Constrictive Remodeling after Angioplasty in Rats: Augmentative Effect of alpha V beta 3 Receptor Blockade.
Atherosclerosis, 163(2):269-277,2002 (IF=3.962)
Shmuel Banai, M.D.
April 2013
6
44. Keren A, Banai S,: Transcatheter ablation of septal hypertrophy (TASH): a promising alternative to surgery in hypertrophic obstructive cardiomyopathy. Isr Med Assoc J, 2002;4:114-116
45. Karck M, Meliss R, Hestermann M, Mengel M, Pethig K, Levitzki A, Banai S, Golomb G and Haverich A:
Inhibition of aortic allograft vasculopathy by local delivery of PDGF-receptor tyrosine kinase blocker AG-1295.
Transplantation 2002, 74(9);1335-1341
46. Almagor M, Keren A, Banai S,:
Increased C-reactive protein Level after Coronary Stent Implantation in Patients with Stable Coronary Artery Disease.
Am Heart J. 2003 Feb;145(2):248-53 (IF=4.651)
47. Gazit A, Yeeb K, Ueckerc A, Böhmerc FD, Sjöblomd T, Östmand A, Waltenbergere J, Golomb G, Banai S, Heinrichb MC, Levitzki A.
Tricyclic Quinoxalines as Potent Kinase Inhibitors of PDGFR kinase, Flt3 and Kit
Bioorganic and medicinal Chemistry, 2003;11:2007-2018
48. Banai S, Selitser V, Keren A, Benhorin J, Ben Shitrit O, Yalon S, Halperin E:
The Incidence of Bacteremia Following Cardiac Catheterizations and Percutaneous Coronary Interventions: A prospective study of 960 consecutive procedures.
Am J Cardiol, 2003;92:1004-1007 (IF=3.368)
49. Banai S, Chorny M, Gertz SD, Fishbein I, Gao J, Perez L, Lazarovichi L, Gazit A, Levitzki A, Golomb G:
Locally Delivered Nanoencapsulated Tyrphostin (AGL-2043) Reduces Neointima Formation in Balloon-injured Rat Carotid and Stented Porcine Coronary Arteries.
Biomaterials 2005 ;26:451-461
50. Banai S, Gertz SD, Golomb G, Gavish L, Chorny M, Perez L, Lazarovichi G; Ianculuvich M, Hoffmann M, Orlowski M, Levitzki A:,
Tyrphostin AGL-2043 eluting stent reduces neointima formation in porcine coronary arteries.
Cardiovasc. Research 2004;64:165-171 (IF=6.064)
51. Brohet C, Banai S, Alings A.M.W., Massaad R, Davies M.J., Allen C:
Shmuel Banai, M.D.
April 2013
7
LDL-C goal attainment with the addition of ezetimibe to on-going simvastatin treatment in coronary heart disease patients with hypercholesterolemia. Current Medical Research and Opinion, 2005;21(4):571-578
52. Rott D, Benhorin J, Keren J, Banai S:
Prediction of Coronary Artery Disease Severity in Patients Referred for Coronary Angiography.
Clinical Cardiology, 2005;28:288-292 (IF-2.95)
53. Mosseri M, Banai S, Jabara R, Lotan C, Rott D:
The Straight Wire Sign: Recognizing Guidwire Exit during Percutaneous Coronary Intervention for chronic total occlusion.
Int J Cardiol. 2007 Apr 4;116(3):e106-8. Epub 2006 Nov 28 (IF=7.078)
54. Banai S, Ben Muvhar S, Parikh KH, Medina A, Sievert H, Seth A, Tsehori J, Paz Y, Sheinfeld A, Keren G:
Coronary Sinus Reducer-Stent for the Treatment of Chronic Refractory Angina Pectoris A prospective, open label, multi-center safety feasibility first-in-man study.
J Am Coll Cardiol, 2007; 49:1783-1789 (IF=14.156)
55. Arbel Y, Eros Y, Rogowski O, Berliner S, Shapira I, Keren G, Vered Y, Banai S:
The Usefulness of Wide Range C-reactive Protein Compared to High Sensitivity C-reactive Protein in Patients with Ischemic Heart Diseases.
Am J Cardiology 2007; 99 (11):1504-1506 (IF=3.368)
56. Keren A, Poteckin M, Mazouz B, Medina A, Banai S, Chenzbraun A, Khoury Z, Levin G: Late in hospital pressure gradient measurements improve prediction of long-term outcome of alcohol septal ablation in hypertrophic cardiomyopathy.
Isr Med Assoc J. 2007 Apr;9(4):239-42
57. Banai S: Pathophysiology of end stage heart failure. Cardiology Today 2007;11(1):14-16
58. Aviram G, Shmilovich H, Finkelstein A, Rosen G, Banai S, Graif M, Keren G.
Coronary ostium-straight tube or funnel-shaped? A computerized tomographic coronary angiography study. Acute Card Care. 2006;8(4):224-8
59. Finkelstein A, Bazan S, Herz I, George J, Halkin A, Miller H, Keren G, Banai S:
Treatment of femoral artery pseudo-aneurysm with Para-aneurysmal saline injection. Am J Cardiol. 2008;101(10):1418-22 (IF=3.368)
Shmuel Banai, M.D.
April 2013
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60. Banai S, Halkin A:
Carotid artery stenting for extra-cranial carotid artery disease.
Cardiology Update and Review. 2008,1:3-8
61. Planer D, Beyar R, Almagor Y, Banai S, Guetta V, Miller H, Kornowski R, Brandes S, Krakover R, Solomon M, Lotan C.
Long-term (>3 Years) outcome and predictors of clinical events after insertion of sirolimus-eluting stent in one or more native coronary arteries.
Am J Cardiol. 2008 Apr 1;101(7):953-9 (IF=3.368)
62. Rind E, Arbel Y, Finkelstein A, Keren G, Banai S:
Angiographic Evaluation of Epicardial and Microvascular Coronary Flow.
Isr Med Assoc J. 2009 Mar;11(3):173-7 (IF=1.018)
63. Epstein H, Rabinovich L, Banai S, Elazar V, Gao J, Chorny M, Danenebrg HD, Golomb G. Predicting in vivo efficacy of potential restenosis therapies by cell culture studies: Species-dependent susceptibility of vascular smooth muscle cells.
The Open Cardiovascular Medicine Journal, 2008,2:60-69
64. Finkelstein A, Keren G, Banai S:
Thrombus aspiration from a coronary artery in primary PCI for acute MI.
Harefuah 2008 Oct;147(10):818-9. Hebrew
65. Qian J, Maehara A, Mintz GS, Margolis MP, Lerman A, Rogers J, Banai S, Kazziha S, Castellanos C, Dani L, Fahy M, Stone GW, Leon MB.
Impact of Gender and Age on In Vivo Virtual Histology–Intravascular Ultrasound Imaging Plaque Characterization (from the global Virtual Histology Intravascular Ultrasound [VH-IVUS] Registry)
The American Journal of Cardiology, 2009;103:1210-1214 (IF=3.368)
66. Justo D, Mashav N, Arbel Y, Kinori M, Steinvil A, Swartzon M, Molat B, Halkin A, Finkelstein A, Heruti R, Banai S:
Increased erythrocyte aggregation in men with coronary artery

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