קרן אברהם

לעדכון

תאריך התחלה: 29/09/2025

Laboratory of Neural and Sensory Genomics

Our research focuses on the discovery and characterization of genes responsible for hereditary hearing loss and neurodevelopmental diseases. Our work covers the transcriptome and epigenome of the auditory and vestibular systems, in order to dissect the regulatory pathways of these systems. This work includes the microRNAs, long non-coding RNAs, methylation and enhancers. My team has studied the mechanisms and pathophysiology of deafness in several mouse models, which mimic human disease. We have created a number of mouse mutants using the gene editing tool CRISPR/Cas9. Moreover, we are using AAV-gene therapy to rescue hearing in mouse models for human deafness. We study the mechanisms of GRIN2D in causing developmental delay and epilepsy, which, like deafness, is a rare disease among a relatively common phenotype of epileptic encephalopathy, as well as Congenital Central Hypoventilation Syndrome (CCHS). The research in our laboratory enables us to understand mechanisms of pathogenesis leading to human disease and the biological pathways required for development and maintenance of the inner ear and the brain.

תאריך התחלה: 03/01/2026

מיקום: אוניברסיטת תל אביב