פרופ' יהודה כרמלי

Education

M.D.                 Ben Gurion University of the Negev, Beer-Sheva, Israel

M.P.H.             Harvard School of Public Health, Cambridge, MA, USA

Academic positions

Professor, Sackler Faculty of Medicine

Research areas

Antibiotics, Antibiotic resistance, The epidemiology of infectious diseases, especially infections acquired in the hospital setting.

List of Publications (2011-2013)

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Adler A, Navon-Venezia S, Moran-Gilad J, Marcos E, Schwartz D, Carmeli Y. Laboratory and clinical evaluation of screening agar plates for detection of carbapenem-resistant Enterobacteriaceae from surveillance rectal swabs. J Clin Microbiol. 2011 Jun;49(6):2239-42.

Andremont A, Bonten M, Kluytmans J, Carmeli Y, Cars O, Harbarth S. Fighting bacterial resistance at the root: need for adapted EMEA guidelines. Lancet Infect Dis. 2011 Jan;11(1):6-8.

Ben-David D, Masarwa S, Navon-Venezia S, Mishali H, Fridental I, Rubinovitch B, Smollan G, Carmeli Y, Schwaber MJ; Israel PACF CRKP (Post-Acute-Care Facility  Carbapenem-Resistant Klebsiella pneumoniae) Working Group. Carbapenem-resistant Klebsiella pneumoniae in post-acute-care facilities in Israel. Infect Control Hosp Epidemiol. 2011 Sep;32(9):845-53.

Carmeli Y, Lidji SK, Shabtai E, Navon-Venezia S, Schwaber MJ. The effects of group 1 versus group 2 carbapenems on imipenem-resistant Pseudomonas aeruginosa: an ecological study. Diagn Microbiol Infect Dis. 2011 Jul;70(3):367-72.

Espinal P, Fugazza G, López Y, Kasma M, Lerman Y, Malhotra-Kumar S, Goossens H, Carmeli Y, Vila J. Dissemination of an NDM-2-producing Acinetobacter baumannii clone in an Israeli rehabilitation center. Antimicrob Agents Chemother. 2011 Nov; 55(11):5396-8.

Hsueh PR, Hoban DJ, Carmeli Y, Chen SY, Desikan S, Alejandria M, Ko WC, Binh TQ. Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region. J Infect. 2011 Aug;63(2):114-23.

Goren MG, Chmelnitsky I, Carmeli Y, Navon-Venezia S. Plasmid-encoded OXA-48 carbapenemase in Escherichia coli from Israel. J Antimicrob Chemother. 2011 Mar;66(3):672-3.

Hawser S, Hoban D, Bouchillon S, Badal R, Carmeli Y, Hawkey P. Antimicrobial  susceptibility of intra-abdominal gram-negative bacilli from Europe: SMART Europe 2008. Eur J Clin Microbiol Infect Dis. 2011 Feb;30(2):173-9.

Lopez JA, Correa A, Navon-Venezia S, Correa AL, Torres JA, Briceño DF, Montealegre MC, Quinn JP, Carmeli Y, Villegas MV. Intercontinental spread from Israel to Colombia of a KPC-3-producing Klebsiella pneumoniae strain. Clin Microbiol Infect. 2011 Jan;17(1):52-6.

Moran Gilad J, Carmeli Y, Schwartz D, Navon-Venezia S. Laboratory evaluation of the CHROMagar KPC medium for identification of carbapenem-nonsusceptible Enterobacteriaceae. Diagn Microbiol Infect Dis. 2011 Aug;70(4):565-7.

Schechner V, Gottesman T, Schwartz O, Korem M, Maor Y, Rahav G, Karplus R, Lazarovitch T, Braun E, Finkelstein R, Lachish T, Wiener-Well Y, Alon D, Chowers M, Bardenstein R, Zimhony O, Paz A, Potasman I, Giladi M, Schwaber MJ, Klarfeld-Lidji S, Hochman M, Marchaim D, Carmeli Y. Pseudomonas aeruginosa bacteremia upon hospital admission: risk factors for mortality and influence of inadequate empirical antimicrobial therapy. Diagn Microbiol Infect Dis. 2011 Sep;71(1):38-45.

Schechner V, Kotlovsky T, Tarabeia J, Kazma M, Schwartz D, Navon-Venezia S, Carmeli Y. Predictors of rectal carriage of carbapenem-resistant Enterobacteriaceae (CRE) among patients with known CRE carriage at their next hospital encounter. Infect Control Hosp Epidemiol. 2011 May;32(5):497-503.

Schwaber MJ, Lev B, Israeli A, Solter E, Smollan G, Rubinovitch B, Shalit I, Carmeli Y, Israel Carbapenem-Resistant Enterobacteriaceae Working Group. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis. 2011 Apr 1;52(7):848-55.

Schwaber MJ, Masarwa S, Navon-Venezia S, Kandlik Y, Chmelnitsky I, Smollan G,  Glick R, Neria G, Carmeli Y. High prevalence of methicillin-resistant Staphylococcus aureus among residents and staff of long-term care facilities, involving joint and parallel evolution. Clin Infect Dis. 2011 Nov;53(9):910-3.

Wernli D, Haustein T, Conly J, Carmeli Y, Kickbusch I, Harbarth S. A call for action: the application of The International Health Regulations to the global threat of antimicrobial resistance. PLoS Med. 2011 Apr;8(4):e1001022.

Adler A, Chmelnitsky I, Shitrit P, Sprecher H, Navon-Venezia S, Embon A, Khabra E, Paitan Y, Keren L, Halperin E, Carmeli Y, Schwaber MJ. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Israel: dissemination of global clones and unique features. J Clin Microbiol. 2012 50:134-137.

Adler A, Gniadkowski M, Baraniak A, Izdebski R, Fiett J, Hryniewicz W, Malhotra-Kumar S, Goossens H, Lammens C, Lerman Y, Kazma M, Kotlovsky T, Carmeli Y, MOSAR WP5 and WP2 study groups. Transmission dynamics of ESBL-producing Escherichia coli clones in rehabilitation wards at a tertiary care centre. Clin Microbiol Infect. 2012 Dec;18(12):E497-505.

Adler A, Paikin S, Sterlin Y, Glick J, Edgar R, Aronov R, Schwaber MJ, Carmeli Y. A swordless knight: epidemiology and molecular characteristics of the blaKPC-negative sequence type 258 Klebsiella pneumoniae clone. J Clin Microbiol. 2012 Oct;50(10):3180-5.

Akova M, Daikos GL, Tzouvelekis L, Carmeli Y. Interventional strategies and current clinical experience with carbapenemase-producing Gram-negative bacteria. Clin Microbiol Infect. 2012 May;18(5):439-48.

Bilavsky E, Lerman Y, Rabinovich A, Salomon J, Lawrence C, Rossini A, Salvia A, Samso JV, Fierro J, Hochman M, Kazma M, Klein A, Schwaber MJ, Carmeli Y, MOSAR WP5 study team. Carriage of methicillin-resistant Staphylococcus aureus on admission to European rehabilitation centres--a prospective study. Clin Microbiol Infect. 2012 Jun;18(6):E164-9.

Cantón R, Akóva M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Miriagou V, Naas T, Rossolini GM, Samuelsen Ø, Seifert H, Woodford N, Nordmann P, European Network on Carbapenemases. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect. 2012 May;18(5):413-31.

Chmelnitsky I, Doniger T, Shklyar M, Naparstek L, Banin E, Edgar R, Carmeli Y. Draft genome sequence of an extremely drug-resistant KPC-producing Klebsiella pneumoniae ST258 epidemic strain. J Bacteriol. 2012 Nov;194(21):6014.

Collins VL, Marchaim D, Pogue JM, Moshos J, Bheemreddy S, Sunkara B, Shallal A, Chugh N, Eiseler S, Bhargava P, Blunden C, Lephart PR, Memon BI, Hayakawa K, Abreu-Lanfranco O, Chopra T, Munoz-Price LS, Carmeli Y, Kaye KS. Efficacy of ertapenem for treatment of bloodstream infections caused by extended-spectrum-β-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother. 2012 Apr;56(4):2173-7.

Feldman N, Adler A, Molshatzki N, Navon-Venezia S, Khabra E, Cohen D, Carmeli Y. Gastrointestinal colonization by KPC-producing Klebsiella pneumoniae following hospital discharge: duration of carriage and risk factors for persistent carriage. Clin Microbiol Infect. 2012 epub ahead of print, PubMed PMID: 23331385.

Gazin M, Lee A, Derde L, Kazma M, Lammens C, Ieven M, Bonten M, Carmeli Y, Harbarth S, Brun-Buisson C, Goossens H, Malhotra-Kumar S, MOSAR WP2 Study Team. Culture-based detection of methicillin-resistant Staphylococcus aureus by a network of European laboratories: an external quality assessment study. Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1765-70.

Grisaru-Soen G, Friedman T, Dollberg S, Mishali H, Carmeli Y. Late-onset bloodstream infections in preterm infants: a 2-year survey. Pediatr Int. 2012 Dec;54(6):748-53..

Moran-Gilad J, Schwartz D, Navon-Venezia S, Carmeli Y. Laboratory evaluation of the ESwab transport system for the recovery of carbapenem-resistant Acinetobacter baumannii. Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1429-33.

Naparstek L, Carmeli Y, Chmelnitsky I, Banin E, Navon-Venezia S. Reduced susceptibility to chlorhexidine among extremely-drug-resistant strains of Klebsiella pneumoniae. J Hosp Infect. 2012 May;81(1):15-9.

Schechner V, Kotlovsky T, Kazma M, Mishali H, Schwartz D, Navon-Venezia S, Schwaber MJ, Carmeli Y. Asymptomatic rectal carriage of bla(KPC) producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected?. Clin Microbiol Infect. 2012 Apr 6;PubMed PMID: 22563800.

Vervoort J, Baraniak A, Gazin M, Sabirova J, Lammens C, Kazma M, Grabowska A, Izdebski R, Carmeli Y, Kumar-Singh S, Gniadkowski M, Goossens H, Malhotra-Kumar S, MOSAR WP2, SATURN WP1 study groups. Characterization of two new CTX-M-25-group extended-spectrum β-lactamase variants identified in Escherichia coli isolates from Israel. PLoS One. 2012;7(9):e46329.

Adler A, Baraniak A, Izdebski R, Fiett J, Gniadkowski M, Hryniewicz W, Salvia A, Rossini A, Goossens H, Malhotra S, Lerman Y, Elenbogen M, Carmeli Y, MOSAR WP5 & WP2 study groups. A binational cohort study of intestinal colonization with extended-spectrum β-lactamase-producing Proteus mirabilis in patients admitted to rehabilitation centres. Clin Microbiol Infect. 2013 Feb;19(2):E51-8.

Arad E, Navon-Venezia S, Gur E, Kuzmenko B, Glick R, Frenkiel-Krispin D, Kramer E, Carmeli Y, Barnea Y. Novel rat model of methicillin-resistant Staphylococcus aureus-infected silicone breast implants: a study of biofilm pathogenesis. Plast Reconstr Surg. 2013 Feb;131(2):205-14. PubMed PMID: 23076419.

Baraniak A, Izdebski R, Fiett J, Sadowy E, Adler A, Kazma M, Salomon J, Lawrence C, Rossini A, Salvia A, Vidal Samso J, Fierro J, Paul M, Lerman Y, Malhotra-Kumar S, Lammens C, Goossens H, Hryniewicz W, Brun-Buisson C, Carmeli Y, Gniadkowski M, on behalf of the MOSAR WP2 & WP5 study groups. Comparative population analysis of Klebsiella pneumoniae with extended-spectrum β-lactamases colonizing patients in rehabilitation centers in four countries. Antimicrob Agents Chemother. 2013, PubMed PMID: 23403417.

Bilavsky E, Pfeffer I, Tarabeia J, Schechner V, Abu-Hanna J, Grisaru-Soen G, Schwartz D, Navon-Venezia S, Carmeli Y. Outbreak of multidrug-resistant Pseudomonas aeruginosa infection following urodynamic studies traced to contaminated transducer. J Hosp Infect. 2013 Apr;83(4):344-6.

Chmelnitsky I, Shklyar M, Hermesh O, Navon-Venezia S, Edgar R, Carmeli Y. Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258. J Antimicrob Chemother. 2013 Jan;68(1):74-83.

Izdebski R, Baraniak A, Fiett J, Adler A, Kazma M, Salomon J, Lawrence C, Rossini A, Salvia A, Vidal Samso J, Fierro J, Paul M, Lerman Y, Malhotra-Kumar S, Lammens C, Goossens H, Hryniewicz W, Brun-Buisson C, Carmeli Y, Gniadkowski M, MOSAR WP2 and WP5 Study Groups. Clonal structure, extended-spectrum β-lactamases, and acquired AmpC-type cephalosporinases of Escherichia coli populations colonizing patients in rehabilitation centers in four countries. Antimicrob Agents Chemother. 2013 Jan;57(1):309-16.

Karfunkel D, Carmeli Y, Chmelnitsky I, Kotlovsky T, Navon-Venezia S. The emergence and dissemination of CTX-M-producing Escherichia coli sequence type 131 causing community-onset bacteremia in Israel. Eur J Clin Microbiol Infect Dis. 2013 Apr;32(4):513-21.

Lerner A, Adler A, Abu-Hanna J, Meitus I, Navon-Venezia S, Carmeli Y. Environmental contamination by carbapenem-resistant Enterobacteriaceae. J Clin Microbiol. 2013 Jan;51(1):177-81.

Lerner A, Romano J, Chmelnitsky I, Navon-Venezia S, Edgar R, Carmeli Y. Rectal Swabs Are Suitable for Quantifying the Carriage Load of KPC-Producing Carbapenem-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2013 Mar;57(3):1474-9.

Schwaber MJ, Navon-Venezia S, Masarwa S, Tirosh-Levy S, Adler A, Chmelnitsky I, Carmeli Y, Klement E, Steinman A. Clonal transmission of a rare methicillin-resistant Staphylococcus aureus genotype between horses and staff at a veterinary teaching hospital. Vet Microbiol. 2013 Mar 23;162(2-4):907-11.

Grants (2011-2013)

European Commission FP6 Grant. MOSAR: Mastering Hospital Antimicrobial Resistance and Its Spread into the Community.

European Commission FP7 Grant. SATURN: Impact of Specific Antibiotic Therapies on the Prevalence of Human Host Resistant Bacteria

European Commission FP7 Grant.  R-GNOSIS: Resistance in Gram-Negative Organisms: Studying Intervention Strategies.

European Commission FP7 Grant. AIDA: Preserving old antibiotics for the future: assessment of clinical efficacy by a pharmacokinetic/pharmacodynamic approach to optimize effectiveness and reduce resistance for off‐patent antibiotics.