High-resolution single-cell atlas of early human brain development

You are cordially invited to a special seminar of the
Department of Cell and Developmental Biology 

By:

Miri Danan-Gotthold, PhD
Department of Molecular Genetics
Weizmann Institute of Science, Israel

High-resolution single-cell atlas of early human brain development

The human brain is formed through a meticulously regulated and extremely complex process. In this study, we performed single-cell RNA-sequencing of more than 1.5 million cells from all brain regions at 5 – 14 post-conceptional weeks and multiplex RNA in situ hybridization. Our analysis unveiled general principles of brain development and delineated differentiation trajectories in various brain regions. In the developing cortex, we identified three distinct molecular programs—cell cycle, differentiation, and maturation—and discovered that differentiation is coupled to cell cycle progression in cortical progenitors. Additionally, our study revealed region-specificity among the arising glial population maturing into distinct pre-astrocytes and pre-oligodendrocyte precursor cells (pre-OPCs). This comprehensive dataset serves as a valuable reference for investigating the cellular mechanisms underlying human neurodevelopment and neurological disorders. 

The Seminar will take place on 
Sunday January 7th 2024, 10:15 – 11:00
At the Faculty of Medicine Slezak Auditorium