פרופ' אילנה לוטן

פיזיולוגיה ופרמקולוגיה אמריטוס
פרופ' אילנה לוטן
טלפון פנימי: 03-6409863
פקס: 03-6409113
משרד: רפואה-סאקלר, 512

Positions

Professor, Department of Physiology & Pharmacology, Sackler Faculty of Medicine

קורות חיים

 

 

EDUCATION

1985 - 1987     Post-doc in Neurobiology, Columbia University, New York.

1981 - 1984     Ph. D. in Biophysics and Pharmacology, Tel Aviv University, Tel Aviv.

1972 - 1975     M. Sc. in Medicinal Chemistry, Tel Aviv University, Tel Aviv.

1969 - 1972     B. Sc. in Chemistry, Hebrew University, Jerusalem.

ACADEMIC APPOINTMENTS

2001-present   Full Professor, Tel Aviv University.  

1997-2001       Associate Professor, Tel Aviv University.

1992-1997       Senior Lecturer, Tel Aviv University.

1987-1992       Research Associate, Tel Aviv University.

 

 

תחומי מחקר

 

 

1)      Study of the novel role of Kv2.1 potassium channel in insulin secretion from pancreatic islet β cells, as a target for novel drug design for the treatment of type-2 diabetes.

2)      Study of structure-function and modulations by presynaptic modulators of Kv2.1 and other Kv channels, specifically KCNQ2 and KCNQ3, important in axonal and synaptic excitability.

3)      Investigating the conformational changes of Syntaxin 1A during exocytosis, using novel fluorescent probes, and their implications exocytosis-related events, in general, and for Kv2.1-induced facilitation of exocytosis.

 

 

פרסומים

 

 

List of Manuscripts

 

Etzioni, A., Siloni, S., Chikvashvilli, D., Strulovich, R., Sachyani, D., Regev, N., Greitzer-Antes, D., Hirsch, J.A. and Lotan, I. (2011) Regulation of Neuronal M-Channel Gating in an Isoform-Specific Manner: Functional Interplay between Calmodulin and Syntaxin 1A. J Neurosci31, 14158-14171.

 

Feinshreiber, L., Singer-Lahat, D., Friedrich, R., Matti, U., Sheinin, A., Yizhar, O., Nachman, R., Chikvashvili, D., Rettig, J., Ashery, U. and Lotan, I. Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells. J Cell Sci123, 1940-1947.

 

Lvov, A., Greitzer, D., Berlin, S., Chikvashvili, D., Tsuk, S., Lotan, I. and Michaelevski, I. (2009) Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating. J Biol Chem284, 28276-28291.

 

Regev, N., Degani-Katzav, N., Korngreen, A., Etzioni, A., Siloni, S., Alaimo, A., Chikvashvili, D., Villarroel, A., Attali, B. and Lotan, I. (2009) Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity. PLoS One4, e6586.

 

Feinshreiber, L., Chikvashvili, D., Michaelevski, I. and Lotan, I. (2009) Syntaxin modulates Kv1.1 through dual action on channel surface expression and conductance. Biochemistry48, 4109-4114.

 

Tsuk, S., Lvov, A., Michaelevski, I., Chikvashvili, D. and Lotan, I. (2008) Formation of the full SNARE complex eliminates interactions of its individual protein components with the Kv2.1 channel. Biochemistry47, 8342-8349.

 

Lvov, A., Chikvashvili, D., Michaelevski, I. and Lotan, I. (2008) VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation. Pflugers Arch456, 1121-1136.

 

Singer-Lahat, D., Chikvashvili, D. and Lotan, I. (2008) Direct interaction of endogenous Kv channels with syntaxin enhances exocytosis by neuroendocrine cells. PLoS One3, e1381.

 

Michaelevski, I., Korngreen, A. and Lotan, I. (2007) Interaction of syntaxin with a single Kv1.1 channel: a possible mechanism for modulating neuronal excitability. Pflugers Arch454, 477-494.

 

Singer-Lahat, D., Sheinin, A., Chikvashvili, D., Tsuk, S., Greitzer, D., Friedrich, R., Feinshreiber, L., Ashery, U., Benveniste, M., Levitan, E.S. and Lotan, I. (2007) K+ channel facilitation of exocytosis by dynamic interaction with syntaxin. J Neurosci27, 1651-1658.

 

 

List of Reviews

 

Michaelevski, I. and Lotan, I. Role of neuronal potassium M-channels in sympathetic regulation of cardiac function. J Physiol589, 2659-2660.

 

Feinshreiber, L., Singer-Lahat, D., Ashery, U. and Lotan, I. (2009) Voltage-gated potassium channel as a facilitator of exocytosis. Ann N Y Acad Sci1152, 87-92.

 

Grants

  • 2014-2018 Israel Science Foundation
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