פרופ' שמעון אפרת

גנטיקה מולשל אדם וביוכמ סגל אקדמי בכיר
פרופ' שמעון אפרת
טלפון פנימי: 03-6407701
טלפון נוסף: 03-6407986
פקס: 03-6409950
משרד: רפואה-סאקלר, 1007

נושאי מחקר

מעבדתי מתמקדת במנגנוני הבקרה של התרבות והתמינות של תאי בטא מייצרי אינסולין באיי הלבלב. תאים אלה נהרסים או אינם מתפקדים באופן תקין בסוכרת. ריפוי המחלה ע"י החלפת התאים הפגועים בתאים תקינים בהשתלה מוגבל ע"י מחסור בתורמי לבלב. מטרת המחקר שלנו היא פיתוח מקורות אלטרנטיביים לתאים מייצרי אינסולין. שתי הגישות העיקריות הן ריבוי והתמינות של תאי ביטא מתורמי לבלב בתרבית, והתמיינות של תאי גזע אנושיים לתאים מייצרי אינסולין. 

 

 

קורות חיים

 

EDUCATION

1985 -  Hebrew University, Jerusalem, Israel, Ph.D., Molecular Biology

                         

POST-GRADUATE TRAINING

1985 - 1988 -  Cold Spring Harbor Laboratory, New York    

                                                       

PROFESSIONAL APPOINTMENTS

1989 - 1993 -  Assistant Professor, Dept. of Molecular Pharmacology                                          

Albert Einstein College of Medicine, New York

Member, Cancer Research Center, Albert Einstein College of Medicine 

 

1989 - 1999 -  Member, Diabetes Research and Training Center,  Albert Einstein College of Medicine                                               

 

1993 - 1998 -  Associate Professor, Dept. of  Molecular Pharmacology,  Albert Einstein College of Medicine                                      

 

1995 - 1997 -  Visiting Associate Professor, Sackler School of Medicine, Tel Aviv University                                

 

1997 - 2007 -  Associate Professor, Sackler School of Medicine, Tel Aviv University                                                 

 

1989 - 1999 -  Professor, Dept. of Molecular Pharmacology, Albert Einstein College of Medicine                                                   

 

1999 - Psesent - Visiting  Professor, Dept. of Molecular Pharmacology,  Albert Einstein College of Medicine                                        

 

2007 - Present - Professor, Sackler School of Medicine, Tel Aviv University    

                            

2008 - Present - Incumbent, The Nancy Gluck Regan Chair in Juvenile Diabetes                             

 

Research

Cell Replacement Therapy for Diabetes

Our research focuses on the development of a cell replacement therapy for diabetes, in which the insulin-producing pancreatic beta cells are destroyed or malfunction. Our approaches for generation of an abundant source of cells for transplantation include expansion and differentiation in tissue culture of beta cells from human organ donors, as well as differentiation of human stem cells into insulin-producing cells.


 

Publications and Grants

Publications

Bar-Nur O, Russ HA, Efrat S, Benvenisty N (2011) Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 9:17-23

 

Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, Toren G, Farhy C, Pasmanik-Chor M, Oron-Karni V, Ravassard P, Efrat S (2011) Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One 6:e25566

 

Bar Y, Russ HA, Anker-Kitai L, Knoller S, Efrat S (2012) Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem 287:17269-17280

 

Lenz A, Toren-Haritan G, Efrat S. (2014) Redifferentiation of Adult Human β Cells Expanded In Vitro by Inhibition of the WNT Pathway. PLoS One. 9:e112914

 

 Nathan G, Kredo-Russo S, Geiger T, Lenz A, Kaspi H, Hornstein E, Efrat S (2015) miR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One 10: e0122108

 

Sintov E, Nathan G, Knoller S, Pasmanik-Chor M, Russ HA, Efrat S (2015) Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro. Sci Rep 5:13024

 

Toren-Haritan G, Efrat S (2015) TGFβ pathway inhibition redifferentiates human pancreatic islet β cells expanded in vitro. PLoS One 10: e0139168

 

 

Reviews

Russ HA, Efrat S (2011) In-vivo functional assessment of engineered human insulin-producing cells. In Cell Transplantation, Soto-Gutierrez A, Navarro-Alvarez N, Fox IJ (eds.), Methods in Bioengineering, Yarmush ML, Langer RS (eds.), Artech House, pp. 35-46

 

Russ HA, Efrat S (2011) Development of human insulin-producing cells for cell therapy of diabetes. Ped Endocrinol Rev 9:590-597

 

Efrat S, Russ HA (2012) Making beta cells from adult tissues. Trends Endocrinol Metab 23:278-285

 

Efrat S (2013) Recent progress in generation of human surrogate beta cells. Curr Opin Endocrinol Diab Obes 20:259-264

 

Bar Y, Efrat S (2014) The Notch pathway in beta-cell growth and differentiation. In The Pancreatic Beta Cell, Litwack G (ed.), Vitamins and Hormones vol. 95, Academic Press/Elsevier, pp. 391-405

 

 

Grants

2011-2014 Beta-cell replacement by human islet beta cells expanded in vitro, Israel Science Foundation (ISF)
2012-2017           Stem cells for biological assays of novel drugs and predictive toxicology, Innovative Medicines Initiative (IMI)
2013-2015   Redifferentiation of expanded human beta-cell-derived cells for cell therapy of diabetes, Israel Ministry of Industry, Trade, and Labor Kamin Program
2013-2017 Generation of human insulin-producing cells by redifferentiation of cells expanded from pancreatic islet beta cells through inhibition of the NOTCH pathway, Israel Science Foundation (ISF)

       

אוניברסיטת תל-אביב, ת.ד. 39040, תל-אביב 6997801
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