סמינר מיוחד של החוג לגנטיקה מולקולרית של האדם וביוכימיה

Dept. of Human Molecular Genetics and Biochemistry

החוג לגנטיקה מולקולרית של האדם ולביוכימיה

You are cordially invited to a seminar of the

Department of Human molecular Genetics and Biochemistry

Sackler Faculty of Medicine

Topic:

Matrix rich tissues - a new paradigm for cellular regulation of homeostasis and repair, from basic science to novel musculoskeletal treatments

By:

Mor Grinstein, Ph.D.

HFSP fellow, Instructor of Medicine

The Center for Regenerative Medicine

MGH and Harvard Medical School

Abstract: Tendons connect and transfer force between the muscles and bones of the body, making them highly prone to injury. Tendon injuries consist 30-50% of all sports and work-related injuries. These common injuries encompass acute tears and rupture, to chronic degradation and deterioration of the tissue, and severely affect the musculoskeletal system. Unfortunately, we have limited knowledge about the identity and molecular mechanisms that regulate tendon cells in postnatal growth, in running regimens and microgravity environments, and mostly in healing following tendon injuries.

In my research I sought to establish a cell-level resolution of tendon behavior. I developed unique tools and platforms that have enabled me to vastly explore the molecular biology of tendons. First, I defined the transition from growth to physiological homeostasis in the tendon. Then, I identified a novel innate stem cell population in the adult tendon, that orchestrates tendon healing, and whose capacity for repair is governed by Wnt signaling. Currently, I explore the effect of exercise on tendon biology in adult mice and humans.  My future lab will build off of my current work and focus on understanding how cells in matrix-rich tissues, such as the tendon, sense, react and integrate different physical and biochemical signals at the tissue, cellular, and subcellular level.

The Seminar will take place on:

Monday, December 13th, 2021 at 13:15 PM

Sackler Faculty of Medicine Building, Room 100.