סמינר מיוחד של החוג לגנטיקה מולקולרית של האדם וביוכימיה
Dept. of Human Molecular Genetics and Biochemistry
Dept. of Human Molecular Genetics and Biochemistry
החוג לגנטיקה מולקולרית של האדם ולביוכימיה
You are cordially invited to the special seminar of the
Department of Human molecular Genetics and Biochemistry
Sackler Faculty of Medicine
By:
Aldema Sas-Chen, Ph.D.
Department of Molecular Genetics,
Weizmann Institute of Science
Title:
RNA modifications in human disease and across evolution
Abstract: The field of epitranscriptomics defines the landscape of >150 types of RNA modifications that regulate the life cycle of RNA, and act as instrumental players in dynamically modulating cellular outputs. A pivotal milestone in elucidating the mechanisms of action of RNA modifications is the development of high-resolution maps, which chart the landscape of the different modifications across various RNA types. Here I describe a novel high-throughput method we developed for mapping RNA acetylation (N4-acetylcytidine; ac4C) at single base resolution. Using this method, we conducted a cross-evolutionary profiling of ac4C and found that it is catalyzed at a conserved sequence motif. Our studies further uncovered that RNA acetylation is dynamically regulated by environmental cues and contributes to RNA thermostabilization. In addition, I discuss the profiling of modifications in mitochondrial RNA and the identification of disease-related enzymes that catalyze them. These studies quantitatively define the landscape of various RNA modifications, providing a technical and conceptual foundation for elucidating their role in biology and disease.
The Seminar will take place on
Thursday, December 3rd, 2020 at 10:00 AM,
via Zoom:
https://us02web.zoom.us/j/89032761482
Meeting ID: 890 3276 1482