Education:
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1968‑1975 |
Tel Aviv University, Medicine, M.D. 1976 |
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1980‑1981 |
Tel Aviv University, Philosophy, B.A. 1981 |
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1985 |
Board Certified in Cardiology – Israel |
Academic and other positions
Head – Department of Cardiology , Tel Aviv Medical Center
Professor of Cardiology, Tel Aviv University Sackler School of Medicine.
The Chaim Sheba Extraordinary Chair of Cardiology
In vivo models for cardiorenal syndrome and mitral regurgitation
For several years, we have been carrying out an intensive research program on the pathophysiological connections between the heart and the kidney in cardiorenal syndrome (CRS) using a rat model in which an acute MI is induced by permanent ligation of the left anterior descending coronary artery on the background of chronic kidney disease (CKD) (5/6 nephrectomy carried out in two subsequent surgeries). Our preliminary data focus on four main topics:
A) We have demonstrated that CKD alone is sufficient to induce high levels of interstitial fibrosis in the LV, although cardiac function measured by echocardiography was still normal.
B) We have recently shown that adoptive transfer of regulatory T cells at the peri-infarct region after experimental MI in rats, reduces infarct size and attenuates cardiac remodeling in the healing processes of the infarcted LV.
C) We are currently investigating the potential changes in Ca2+homeostasis, the expression levels of Ca2+-channel proteins, as well as the spatial modifications in the cellular organelles in cardiomyocytes of the insulted LV, aiming to gain understanding of the subcellular dysfunction in CRS
D) We could show for the first time that TRP Vallinoid 2 channels, which are highly abundant in neurons and inflammatory cells and mildly expressed in healthy cardiomyocytes [65], are highly expressed in the heart in both cardiomyocytes and infiltrating immune cells upon acute MI (Entin-Meer et al, unpublished data). We have also shown that HL-1 murine atrial cardiomyocytes exposed to serum free and hypoxic conditions (1% O2) responded with enhanced TRP Vallinoid 2 channel expression, as documented by flow cytometry, compared to serum free only or to full medium.
H) We have recently established a rat model for mitral regurgitation. We are going to look into the pathophysiology of changes observed the myocardium in mitral valve disease including the potential re-expression of stem cell markers upon mitral damage.
Clinical Research:
Long term follow up of patients with Coronary artery disease: A large database that includes extensive clinical information as well as a serum bank was established years ago and is called TAPAS. All patients with acute coronary syndromes or stable coronary artery disease who undergo cardiac catheterization are included in the Registry. The patients are followed on a regular basis and the clinical as well as laboratory information is recorded. Multiple studies were published based on the rigorous database.
TAVI follow up registry:
At the Tel Aviv Medical Center we perform complex cardiac interventions including aortic valve implantations. These novel interventions are the forefront of interventional cardiology. All our patients are being steadily followed in the clinic with meticulous echocardiographic and laboratory studies. Research projects have been initiated to try and evaluate thoroughly the long term outcome of these patients.
Electrophysiology:
This area of clinical research has a worldwide recognition. The team in our department is involved in research of arrhythmia in the post MI patients, in patients with various cardiomyopathies and importantly channelopaties such and long QT, Brugada, short QT and other fascinating mechanisms.
List of publications (2008-2012)
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Mausner-Fainberg K., Luboshits G., Mor A., Maysel-Auslender S., Rubinstein A., Keren G., George J.: The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells. Atherosclerosis, Vol. 197(2), pp. 829-39, 2008. |
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Michowitz Y., Arbel Y., Wexler D., Sheps D., Rogowski O., Shapira I., Berliner S., Keren G., George J., Roth A.: Predictive value of high sensitivity CRP in patients with diastolic heart failure. Int J Cardiol, Vol. 25(3), pp. 347-51, 2008.
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Finkelstein A., Bazan S., Halkin A., Herz I., George J., Miller HI., Keren G., Banai S.: Treatment of post-catheterization femoral artery pseudo-aneurysm with para-aneurysmal saline injection. Am J Cardiol, Vol. 101(10), pp. 1418-22, 2008.
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Mor A., Keren G., Kloog Y., George J.: N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells. Eur J Immunol, Vol. 38(6), pp. 1493-502, 2008.
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Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G., George J.: Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol,Vol. 38(9), pp. 2412-8, 2008.
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Geft D, Schwartzenberg S, Rogowsky O, Finkelstein A, Ablin J, Maysel-Auslender S, Wexler D, Keren G., George J.: Circulating apoptotic progenitor cells in patients with congestive heart failure. PLoS One, Vol. 3(9), e3238, 2008.
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Ben-Shoshan J, Schwartz S, Luboshits G, Maysel-Auslender S, Barzelay A, Polak-Charcon S, Tzahor E, Barshack I, Barak A, Levkovitch-Verbin H, Keren G., George J.: Stem Cells,Vol. 26(10), pp.2634-43, 2008.
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Finkelstein A, Keren G., Banai S.: Harefuah, Vol, 147(10), pp. 818-9. Hebrew.
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Barsheshet A., Barshack I., Keren P., Keren G., George J.: Whole-body hyperthermia attenuates experimental autoimmune myocarditis in the rat. Cardiovasc Pathol, Vol, 17(6), pp. 375-81, 2008.
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Michowitz Y, Kisil S., Guzner-Gur H., Rubinstein A., Wexler D., Sheps D., Keren G., George J.: Isr Med Assoc J, Vol. 10(12), pp. 884-8, 2008.
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Mausner-Fainberg K, Luboshits G., Mor A., Maysel-Auslender S., Rubinstein A., Keren G., George J.: The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells. Atherosclerosis,Vol. 197(2), pp. 829-39, 2008.
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Ben-Shoshan J., Maysel-Auslender S., Luboshits G, Barshack I., Polak-Charcon S., Tzahor E., Keren G., George J.: Hypoxia-inducible factor-1alpha and -2alpha additively promote endothelial vasculogenic properties. J Vasc Res, Vol. 46(4), pp. 299-310, 2009.
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Adler A., Afek A., Levy Y., Keren G., George J.: Nat Clin Pract Cardiovasc Med, Vol. 6(3), pp. 215-8, 2009.
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Ben-Shoshan J., Afek A, Maysel-Auslender S., Barzelay A., Rubinstein A., Keren G., George J.: HIF-1alpha overexpression and experimental murine atherosclerosis. Arterioscler Thromb Vasc Biol, Vol. 29(5), pp. 665-70, 2009.
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Shmilovich H., Ben-Shoshan J., Tal R, Afek A., Barshack I, Maysel-Auslander S., Harats D., Keren G., George J.: B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells. Tissue Eng Part A, Vol. 15(9), pp. 2741-9, 2009.
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Afek A., Kogan E., Maysel-Auslender S., Mor A., Regev E., Rubinstein A., Keren G., George J.: Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice. Microvasc Res, Vol. 77(3), pp. 364-9, 2009.
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Pando R., Cheporko Y., Haklai R., Maysel-Auslender S., Keren G., George J., Porat E., Sagie A., Kloog Y., Hochhauser E.: Ras inhibition attenuates myocardial ischemia-reperfusion injury. Biochem Pharmacol, Vol. 77(10), pp. 1593-601, 2009.
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Mor A., Kloog Y., Keren G., George J.: Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. Eur J Pharmacol, Vol. 616(1-3), pp. 301-5, 2009.
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Rind E., Arbel Y., Finkelstein A., Keren G., Banai S.: Angiographic evaluation of epicardial and microvascular coronary flow. Isr Med Assoc J, Vol. 11(3), pp. 173-7, 2009. Review.
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Shoenfeld Y., Shemer J., Keren G., Blachar Y., Eidelman LA., Borow M.: British medical journals play politics. Isr Med Assoc J, Vol. 11(6), pp. 325-7, 2009.
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Charach G., George J., Afek A., Wexler D., Sheps D., Keren G., Rubinstein A.: Antibodies to oxidized LDL as predictors of morbidity and mortality in patients with chronic heart failure. J Card Fail,Vol. 15(9), pp. 770-4, 2009.
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Schwartzenberg S., Halkin A., Finkelstein A., Keren G., Banai S.: [The no-reflow phenomenon following percutaneous coronary intervention] Harefuah, Vol. 148(6), pp. 381-5, 411, 2009. Review. Hebrew.
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Schwartzenberg S., Sherez J., Wexler D., Aviram G., Keren G.: Isolated ventricular non-compaction: an underdiagnosed cause of congestive heart failure. Isr Med Assoc J, Vol. 11(7), pp. 426-9, 2009. Review.
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Barzelay A., Ben-Shoshan J., Entin-Meer M., Maysel-Auslender S., Afek A., Barshack I., Keren G., George J.: A potential role for islet-1 in post-natal angiogenesis and vasculogenesis. Thromb Haemost, Vol. 103(1), pp.188-97, 2010.
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Shoenfeld Y., Shemer J., Keren G.: [Is it worthwhile to be a reviewer for a medical-scientific journal?] Harefuah, Vol. 148(12), pp. 824, 2009. Hebrew.
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Finkelstein A., Keren G., Banai S.: Treatment of severe valvular aortic stenosis and subvalvular discrete subaortic stenosis and septal hypertrophy with Percutaneous CoreValve Aortic Valve Implantation. Catheter Cardiovasc Interv, Vol. 75(5), pp. 801-3, 2010.
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Charach G., George J., Roth A., Rogowski O., Wexler D., Sheps D., Grosskopf I., Weintraub M., Keren G., Rubinstein A.: Baseline low-density lipoprotein cholesterol levels and outcome in patients with heart failure. Am J Cardiol, Vol. 105(1), pp. 100-4, 2010.
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Steinvil A., Berliner S., Shapira I., Rogowski O., Justo D., George J., Halkin A., Keren G., Finkelstein A., Banai S., Arbel Y.: Time to rheology in acute myocardial infarction: inflammation and erythrocyte aggregation as a consequence and not necessarily as precursors of the disease. Clin Res Cardiol, Vol. 99(10), pp. 651-6, 2010.
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Aviram G., Steinvil A., Berliner S., Rosen G., Sosna J., Man A., Keren G., Rogowski O.: The association between the embolic load and atrial size in acute pulmonary embolism. J Thromb Haemost, Vol. 9(2) pp. 293-9, 2011.
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Steinvil A, Banai S, Leshem-Rubinow E, Rogowski O, Halkin A, Keren G, Finkelstein A, Chundadze T, Berliner S, Arbel Y.: The development of anemia of inflammation during acute myocardial infarction. Int J Cardiol, 2010 Nov 15
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Danenberg H., Finkelstein A., Kornowski R., Segev A., Dvir D., Gilon D., Keren G., Sagie A., Feinberg M., Schwammenthal E., Banai S., Lotan C., Guetta V.: Percutaneous implantation of the self-expandable CoreValve for high risk patients with severe aortic valve stenosis: early Israeli experience. Isr Med Assoc J, Vol. 12(8), pp. 468-71, 2010.
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Schwartzenberg S., Afek A., Charach G., Rubinstein A., Ben-Shoshan Y., Kissil S., Maisel-Auslender S., Keren G., George J.: Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome. World J Cardiol, Vol. 2(9), pp. 299-304, 2010.
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Finkelstein A., Schwartzenberg S., Bar L., Levy Y., Halkin A., Herz I., Bazan S., Massachi R., Banal S., Keren G., George J.: Comparative efficacy analysis of an aspiration device before primary angioplasty in patients with acute myocardial infarction: a single-center experience. Isr Med Assoc J,Vol. 12(11), pp. 692-6, 2010.
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Charach G., Grosskopf I., Roth A., Afek A., Wexler D., Sheps D., Weintraub M., Rabinovich A., Keren G., George J.: Usefulness of total lymphocyte count as predictor of outcome in patients with chronic heart failure. Am J Cardiol, Vol. 107(9) pp. 1353-6, 2011.
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Keren G.: Cardiovascular medicine and the Israel Heart Society. Eur Heart J, Vol. 32(12) pp. 1434-5, 2011.
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Abu Fanne R, Banai S, Chorin U, Rogowski O, Keren G., Roth A.: Diagnostic yield of extensive infectious panel testing in acute pericarditis. Cardiology, Vol. 119(3) pp.134-9, 2011.
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Shoenfeld Y, Shemer J, Keren G.: The future of medicine in Israel. Harefuah, Vol. 150(8) pp. 624, 2011. Hebrew.
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Shoenfeld Y, Keren G., Shemer J.: The search for medical information: the Israel Medical Association publishes update journals. Harefuah, Vol. 150(9) pp. 694-5, 2011. Hebrew
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Arbel Y, Banai S, Benhorin J, Finkelstein A, Herz I, Halkin A, Keren G., Yedgar S, Barashtein G, Berliner S.: Erythrocyte aggregation as a cause of slow flow in patients of acute coronary syndromes. Int J Cardiol, Vol. 154(3) pp. 322-7, 2012.
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Aviram G, Cohen D, Steinvil A, Shmueli H, Keren G., Banai S, Berliner S, Rogowski O.: Significance of reflux of contrast medium into the inferior vena cava on computerized tomographic pulmonary angiogram. Am J Cardiol, Vol. 109(3) pp. 432-7, 2012.
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Arbel Y., Rind E., Banai S., Halkin A., Berliner S., Herz I, Mashav N., Thurm T., Keren G., Finkelstein A.: Prevalence and predictors of slow flow in angiographically normal coronary arteries. Clin Hemorheol Microcirc, 2012 Mar 2
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Ish-Shalom M., Sack J., Vechoropoulos M., Shaish A., Entin-Meer M., Kamari Y., Maysel-Auslender S., Keren G., Harats D., Stern N., Tordjman K.: Low-dose calcitriol decreases aortic Renin, blood pressure, and atherosclerosis in apoe-null mice. J Atheroscler Thromb, Vol. 19(5) pp. 422-34, 2012.
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Shoenfeld Y., Shemer J., Keren G., Blachar Y., Eidelman L., Borow M.: The games go on: British Medical Journals play politics, again. Isr Med Assoc J, Vol.14(2) pp, 82-3, 2012.
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Barzelay A., Hochhauser E., Entin-Meer M., Chepurko Y., Birk E., Afek A., Barshack I., Pinhas L., Rivo Y., Ben-Shoshan J., Maysel-Auslender S., Keren G., George J.: Islet-1 gene delivery improves myocardial performance after experimental infarction. Atherosclerosi, Vol. 223(2) pp. 284-90, 2012.
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Aviram G., Sirota-Cohen C., Steinvil A., Keren G., Banai S., Sosna J., Berliner S., Rogowski O.: Automated volumetric analysis of four cardiac chambers in pulmonary embolism. A novel technology for fast risk stratification. Thromb Haemost, Vol. 108(2) pp. 384-93, 2012.
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Entin-Meer M., Ben-Shoshan J., Maysel-Auslender S., Levy R., Goryainov P., Schwartz I., Barshack I., Avivi C., Sharir R., Keren G.: Accelerated Renal Fibrosis in Cardiorenal Syndrome Is Associated with Long-Term Increase in Urine Neutrophil Gelatinase-Associated Lipocalin Levels. Am J Nephrol, Vol. 36(2) pp. 190-200, 2012.
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Shoenfeld Y., Keren G.: [Will I be a good doctor?] Harefuah. Vol. 151(6) pp. 372-3, 2012. Hebrew
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Arbel Y., Finkelstein A., Halkin A., Birati EY., Revivo M., Zuzut M., Shevach A., Berliner S., Herz I., Keren G., Banai S.: Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis.Vol. 225(2) pp. 456-60, 2012.
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Ben-Shoshan J., Entin-Meer M., Guzner-Gur H., Keren G.: The cardiorenal syndrome: a mutual approach to concomitant cardiac and renal failure. Isr Med Assoc J.Vol. 14(9) pp. 570-6, 2012. Review.
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Wasserman A., Ben-Shoshan J., Entin-Meer M., Maysel-Auslender S., Guzner-Gur H., Keren G.: Interleukin-33 augments Treg cell levels: a flaw mechanism in atherosclerosis. Isr Med Assoc J.Vol. 14(10) pp. 620-3, 2012.
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Keren G., Shemer J., Shoenfeld Y.: [In Process Citation]. Harefuah. Vol. 151(10) pp. 600-2, 607, 2012. Hebrew.
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Arbel Y., Halkin A., Finkelstein A., Revivo M., Berliner S., Herz I., Keren G., Banai S.: Impact of Estimated Glomerular Filtration Rate on Vascular Disease Extent and Adverse Cardiovascular Events in Patients Without Chronic Kidney Disease. Can J Cardiol. 2013 Jan 11.
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Shacham Y., Birati EY., Rogovski O., Cogan Y., Keren G., Roth A.: Left ventricular thrombus formation and bleeding complications during continuous in-hospital anticoagulation for acute anterior myocardial infarction. Isr Med Assoc J. Vol. 14(12) pp. 742-6, 2012.
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Grants (2008-2012)
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2011-2014 |
Genetic, immunogenic and calcium signaling determinants of disease progression in an experimental model of cardiorenal syndrome. |
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2010 - 2014 |
Cell or ligand based therapy for ACS |
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2010 - 2012 |
The involvement of miR 17-92 cluster in experimental acute MI. Tel-Aviv University |
